Cytoscaffolds 0.0 / 5 ? Veterinary ScienceBiology of cellsUniversityAll boards Created by: CharlottehenCreated on: 14-11-18 14:54 What is a cytoscaffold? Complex network of filamentous proteins extending through the cytoplasm 1 of 12 Functions of cytoscaffolds... Cell shape, anchoring organelles, organelle movement, tensile strength, cell polarity, chromosome movement, motility 2 of 12 What is the structure of an Intermediate Filament? 10nm diameter, 8 stranded rope like polymer, strands twist to form a hollow tube (protofilament) 3 of 12 Examples of Intermediate Filaments... Keratin, Vimentin, Desmin, GFAP, Neurofilament proteins, Lamins 4 of 12 Epidermolysis Bullosa Genetic disease caused due to keratin mutation 5 of 12 Do Intermediate filaments require an energy source? No and they don't require a cofactor either 6 of 12 What do intermediate filaments not bind to? Nucleotides 7 of 12 What is the structure of Microtubules? 25nm diameter, hollow tubes up to 13 strands each composed of alpha beta tubular dimers 8 of 12 What energy source do microtubules use? Use GTP to form the hollow tubes 9 of 12 What regulatory protein is used to stabilise microtubules? Tau protein 10 of 12 Define anterograde Transport Fromm cell body towards the synapse 11 of 12 Define retrograde transport from synapse to cell body 12 of 12
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