Cytoscaffolds

What is a cytoscaffold?
Complex network of filamentous proteins extending through the cytoplasm
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Functions of cytoscaffolds...
Cell shape, anchoring organelles, organelle movement, tensile strength, cell polarity, chromosome movement, motility
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What is the structure of an Intermediate Filament?
10nm diameter, 8 stranded rope like polymer, strands twist to form a hollow tube (protofilament)
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Examples of Intermediate Filaments...
Keratin, Vimentin, Desmin, GFAP, Neurofilament proteins, Lamins
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Epidermolysis Bullosa
Genetic disease caused due to keratin mutation
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Do Intermediate filaments require an energy source?
No and they don't require a cofactor either
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What do intermediate filaments not bind to?
Nucleotides
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What is the structure of Microtubules?
25nm diameter, hollow tubes up to 13 strands each composed of alpha beta tubular dimers
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What energy source do microtubules use?
Use GTP to form the hollow tubes
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What regulatory protein is used to stabilise microtubules?
Tau protein
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Define anterograde
Transport Fromm cell body towards the synapse
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Define retrograde
transport from synapse to cell body
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Card 2

Front

Functions of cytoscaffolds...

Back

Cell shape, anchoring organelles, organelle movement, tensile strength, cell polarity, chromosome movement, motility

Card 3

Front

What is the structure of an Intermediate Filament?

Back

Preview of the front of card 3

Card 4

Front

Examples of Intermediate Filaments...

Back

Preview of the front of card 4

Card 5

Front

Epidermolysis Bullosa

Back

Preview of the front of card 5
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