Chris Johnson L7

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  • Created by: Rscottqub
  • Created on: 29-03-19 18:34
what is the BBB
semi permeable membrane- highly selective - keeps pathogens and chemicals out
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what is the BBB highly perm to
water, lipid sol subatnces (alcohol/anesthtic)
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Problem about BBB
if problem with the brain- very hard to treat with drugs - esp if drugs are water sol
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BBB also prevents what entering
proteins- can be a problem for protein based drugs
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how do we over come this?
using precursor molecules which can pass- bind drug to these molecules
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BBB movement mechanism
AT for transport of glucose - the only thing the brain can respire . also mvt of hormones
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Certain areas of the BBB are permeable these are...
parts of hypothalamus, pineal gland, area postrema
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These areas are sensitive to
osmolarity, glucose, Ang II
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what can happen to the BB during infection
it can break down
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Hypothalmus
small part of the brain - makes up less than 1% of brain - but controls many things
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What does Hypo control
homeostatis , behavious - due to connections with areas assoc with behaviour i.e midbrain, thalmus+cortex, post and anter pituitary
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Where is the pituitary located
hangs below hypo
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what does hypo regulate
1. GI + feeding, 2. CV reg 3. reg of body water 4. control of hormones 4. temp control
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1. GI and feeding
monitors blood glucose and AAs to produce feeling of hunger . alsow controls feeding patterns ie licking lips /swallowing
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2. CV reg
can act via brainstem to Increase/decrease HR/BP
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3. water
osmoreceptors , thirst centres, ADH
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4. Hormones
pituitary glands - LH, FSH, ADH etc
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Set point is
37 degrees
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locations of temp receptors
hypo, skin, s.c
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a change of what can initiate temp control mechanism
<0.2 degrees
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if too hot
Vasdilation- increase heat loss. Hairs lie flat. sweating. increase respiration. seek shelter . spread out
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too cold
vasocontraiction - reduce heat loss. piloerection - hairs stand up - layer of air insulation. Shivering . put on extra clothes curl up in ball
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Shifts in set point
exercise can induce a shift in the set point this is normal
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Fever
fever causes rising of the bodys set temp to 37+. This activates heat loss mechanisms . If too high dangerous as proteins denature and can casue brain damage if 41+
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treatment of fever
NSAIDS- they prevnt prostaglandin production
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Other cards in this set

Card 2

Front

what is the BBB highly perm to

Back

water, lipid sol subatnces (alcohol/anesthtic)

Card 3

Front

Problem about BBB

Back

Preview of the front of card 3

Card 4

Front

BBB also prevents what entering

Back

Preview of the front of card 4

Card 5

Front

how do we over come this?

Back

Preview of the front of card 5
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