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6. FAP is caused by mutations in which gene?
- APC gene
- mismatched repair genes
7. A mutation that leads to the development of a hallmark of cancer is know of what?
- driver mutation
- passenger mutation
8. successive acquisition of mutations which are then replicated and outcompete original genes
- linear evolution
- branched evolution
9. tumour suppressor genes typically follow which inheritance pattern?
- X linked
- multifactoral
- autosomal dominant
- autosomal recessive
10. "Different cancers can be caused by mutations in different genes"
- homogeneity
- linear evolution
- heterogenicity
- Hayflick limit
11. P53 production is mediated by which of the following:
- -ve feedback loop with itself
- MDM3
- MDM2
- RAS proteins
12. carcinomas are caused by mutations in which genes?
- P53 genes
- Rb genes
- RAS genes
13. proto-oncogene genes typically follow which inheritance pattern?
- X linked
- autosomal recessive
- autosomal dominant
- mitochondrial
14. "additional driver mutation that gives rise to a benign tumour" describes which of the three strikes needed for cancer development?
- expansion phase
- breakthrough phase
- invasive phase
15. P53 is what type of gene?
- tumour suppressor
- proto-oncogene