Brunner - MAOA deficiency

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What was the aim of Brunner's research?
To explain the behaviour of 5 males in the Netherlands where they were affected by borderline mental retardation and violent behaviour.
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What did the behaviour shown by them include?
Arson, exhibitionism, impulsive aggression and attempted ****.
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Who were the participants in Brunner's research?
5 males from one family in the Netherlands.
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Describe the methodology used in Brunner's study
Data was collected through urine samples over a 24 hour period.
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What were the results found from the tests?
Tests found disturbed monoamine metabolism associated with a deficit of the enzyme monoamine oxidase A (MAOA).
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What was identified in each of the 5 males?
A point mutation was identified in the x chromosome of the gene responsible for production of MAOA.
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What were the conclusions drawn about the effects of an MAOA deficiency?
MAOA is involved in serotonin metabolism. The defect in the gene leading to impaired serotonin metabolism is likely to be responsible for the mental retardation and violent behaviour in the family.
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What was the MAOA deficiency associated with?
A recognisable behavioural phenotype.
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What did this phenotype account for?
The inability to regulate their aggression. Not all of the males were affected.
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Is this research generalisable?
It is a rare condition so cannot be generalised very far.
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Card 2

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What did the behaviour shown by them include?

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Arson, exhibitionism, impulsive aggression and attempted ****.

Card 3

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Who were the participants in Brunner's research?

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Card 4

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Describe the methodology used in Brunner's study

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Card 5

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What were the results found from the tests?

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