What type of current is formed when Ca ions move into a cell; inwardly negative or outwardly positive?
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Card 7
Front
How many alternative splicing loci are there for Cav 1.2 and how many possible variants of the protein can be made?
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Card 8
Front
What is the role of t-tubules close to the sarcoplasmic reticulum in the heart and muscles?
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Card 9
Front
Cav 1.2 channels can be both voltage and Cav dependently inactivated, hence what are the two possible inactivation processes possible?
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Card 10
Front
How is a 2:1 atrioventricular block in Timothy Syndrome characterised?
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Card 11
Front
How and why are the ECGs of Timothy Syndrome patients unusual?
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Card 12
Front
Due to the wide variety of symptoms seen in the gain of function disorder; Timothy Syndrome, it isn't always classed an LQTS. Give 4 phenotypic symptoms or observable areas affected resulting from Timothy Syndrome.
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Card 13
Front
When pressure is put on the cardiac system of Timothy Syndrome patients causing them to exhibit ventricular tachycardia, what major cardiac event does this increase the risk of?
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Card 14
Front
In a study done on 17 children with Timothy Syndrome, 10 died during the study, 12/17 experienced life threatening arrhythmias. Why did the 7 survivors experience cognitive impairment?
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Card 15
Front
What was concluded to be the cause of Timothy Syndrome upon finding it was common in 13 of the 17 patients seen but not in controls?
