An example of a PCSK9 inhibitor (PCSK9 promotes the uptake of LDL receptors in the liver, causing them to degrade so uptake of lipid is reduced). It is used as an additive as it is very expensive
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Card 17
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A drug class which increases production of lipoprotein lipase and HDL, reduces production of VLDLs, reduces TG levels and increases LDL uptake. Examples: benzafibrate and gemfibrozil. Side effect of myositis
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Card 18
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These are drugs which are used to bind to bile acids so they cannot emulsify fats - both the fat and the bile acids are lost in the stool. There is less cholesterol absorbed and increased expression of LDL receptors. GI side effects. Not first line
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Card 19
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A drug which inhibits intestinal absorption of cholesterol. There is no effect on absorption of fat-soluble vitamins and it is more potent than resins
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Card 20
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A drug which reduces synthesis of TGs; decreases levels of LDL and VLDL; increases HDL. Used in combination with statins and resins. Common side effects are intense flush and pruritis and GI upset. Risk of jaundice with high doses
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Card 21
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This can be given to make eicosanoids which are less likely to cause clotting, therefore it can be used to improve survival after MI. Impact on lipids is not relevant
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Card 22
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The drug class given in primary prevention of cardiovascular events and in all diabetics over 40 yrs old (can be combined with ezetimibe)
