Axonal path finding cell dev 12

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  • Created by: Amh
  • Created on: 15-05-16 13:14
what guides axons in the developing embryo
growth cones
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what are the 2 components of growth cones
Filapodia, lamillopodia
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what guides groth
solubule and substrate bound factors
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How do commissural axons cross the midline
through a complex Slit Robo interaction
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which axons arent allowed to cross midline
ipsilateral axons
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When there is an attractive signal what happens to fillapodia
microfilaments and microtubules accumulate at the contact side
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what are the mechanisms of axonal pathfinding
stereotropism, hapotaxis, chemotropism
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what is stereotropism
channels and tunnels
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what is hapotaxis
movement of growthh cones along substrate bound molecules e.g. molecules of ECM or Selective fasciculation of axons
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what is chemotropism
diffusible factors
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what aer the physical barriers of sterotropism
collagen fibres, plastic barriers, artificial substrates, tunnels
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What key features of ecm facilitate hapoptosis
Glycoproteins, and proteoglycans
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Why are cell cell adhesions important
Cell adhesion proteins control motility and guide forward movement
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What are some examples of cll adhesion molecules
Classical Cadherins (E,N, P, VE), homophilic binding, associated with cytoskeleton (actin filaments) via catenins. Ig family members (N-CAM, ICAM), homo- and heterophilic binding
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What are come example of cell-matrix adhesion molecule
integrins, and transmembrane proetoglycans
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what affects fasciculation
fascicilin
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what do chemorepullsants do and give an example
they are repulsive factors that lead to growth cone collapse. Collapsin s an example
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Which axons' pathfinding is based on repulsive factors
DRG
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Whatt attracts dorsal commissural axons
netrin gradients
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when is netrin in drosophila
the midline
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what is the midline guiance system of drosophila composed of
slit, and robo
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Other cards in this set

Card 2

Front

what are the 2 components of growth cones

Back

Filapodia, lamillopodia

Card 3

Front

what guides groth

Back

Preview of the front of card 3

Card 4

Front

How do commissural axons cross the midline

Back

Preview of the front of card 4

Card 5

Front

which axons arent allowed to cross midline

Back

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