Axonal path finding cell dev 12

HideShow resource information
  • Created by: Amh
  • Created on: 15-05-16 13:14
what guides axons in the developing embryo
growth cones
1 of 21
what are the 2 components of growth cones
Filapodia, lamillopodia
2 of 21
what guides groth
solubule and substrate bound factors
3 of 21
How do commissural axons cross the midline
through a complex Slit Robo interaction
4 of 21
which axons arent allowed to cross midline
ipsilateral axons
5 of 21
When there is an attractive signal what happens to fillapodia
microfilaments and microtubules accumulate at the contact side
6 of 21
what are the mechanisms of axonal pathfinding
stereotropism, hapotaxis, chemotropism
7 of 21
what is stereotropism
channels and tunnels
8 of 21
what is hapotaxis
movement of growthh cones along substrate bound molecules e.g. molecules of ECM or Selective fasciculation of axons
9 of 21
what is chemotropism
diffusible factors
10 of 21
what aer the physical barriers of sterotropism
collagen fibres, plastic barriers, artificial substrates, tunnels
11 of 21
What key features of ecm facilitate hapoptosis
Glycoproteins, and proteoglycans
12 of 21
Why are cell cell adhesions important
Cell adhesion proteins control motility and guide forward movement
13 of 21
What are some examples of cll adhesion molecules
Classical Cadherins (E,N, P, VE), ****philic binding, associated with cytoskeleton (actin filaments) via catenins. Ig family members (N-CAM, ICAM), ****- and heterophilic binding
14 of 21
What are come example of cell-matrix adhesion molecule
integrins, and transmembrane proetoglycans
15 of 21
what affects fasciculation
fascicilin
16 of 21
what do chemorepullsants do and give an example
they are repulsive factors that lead to growth cone collapse. Collapsin s an example
17 of 21
Which axons' pathfinding is based on repulsive factors
DRG
18 of 21
Whatt attracts dorsal commissural axons
netrin gradients
19 of 21
when is netrin in drosophila
the midline
20 of 21
what is the midline guiance system of drosophila composed of
slit, and robo
21 of 21

Other cards in this set

Card 2

Front

what are the 2 components of growth cones

Back

Filapodia, lamillopodia

Card 3

Front

what guides groth

Back

Preview of the front of card 3

Card 4

Front

How do commissural axons cross the midline

Back

Preview of the front of card 4

Card 5

Front

which axons arent allowed to cross midline

Back

Preview of the front of card 5
View more cards

Comments

No comments have yet been made

Similar Biology resources:

See all Biology resources »See all cell dev resources »