Antibody engineering

?
  • Created by: Biokid373
  • Created on: 22-05-22 15:36

1. What is the benefit of non-fucosylated variants of rituximab and trastuzumab?

  • Increased affinity for FcgRiiA and 100 fold more potent ADCC activity
  • Increased affinity for FcgRiiB and 100 fold more potent ADCC activity
  • Increased affinity for FcgRiiA and 100 fold more potent CDC activity
  • Increased affinity for FcgRiiA and 100 fold more potent ADCP activity
1 of 20

Other questions in this quiz

2. With knob into hole method of specific pairing of heavy chains, how many possible products are formed?

  • 8
  • 10
  • 4
  • 6

3. drawback of Bapineuzumab

  • Requires constant high exposure
  • Induces ARIA
  • No accumulation over time

4. What are the CH2 and CH3 domains of Eclizumab from?

  • Mouse IgG2
  • Mouse IgG4
  • Human IgG4
  • Human IgG2

5. Mutations in the CH3 domain and a flexible hinge can be used for...

  • to modulate binding to FcgR and FcRn
  • antibody engineering of bispecific antibodies
  • To increase half-life of antibodies
  • To prevent exchange of Fab arms
View more questions

Comments

No comments have yet been made

Similar Biology resources:

See all Biology resources »See all Antibodies resources »