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2. What are chimeric antibodies?

  • antibodies with domains from two different species
  • Antibodies from one species put into another species
  • Humanised antibodies

3. What happens if TNFalpha activates endothelial cells?

  • They start expressing adhesion molecules leading to recruitment of immune cells and activation of synovial fibroblasts
  • Endothelial cells block the action of inflammatory molecules

4. Why is combination therapy beneficial when treating B cell lymphoma

  • Higher likelihood of targeting cancerous B cells
  • Blocking FcgRIIb and treating with rituximab ensures that the action of rituximab is not supressed by inhibitory signals of FcgRIIb
  • the B cell wont know whats coming

5. What does Alemtuzumab target?

  • CD3
  • CD52
  • CD20
  • CD27
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