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6. What does increased reticulocyte count indicate in anaemia?

  • Functioning bone marrow
  • Low degree of haemolysis
  • Macrocytic anaemia
  • Iron deficiency

7. What could cause reduced erythrocyte production?

  • Bone marrow suppression or disorders
  • Reduced EPO production (e.g. due to renal failure)
  • All of the above
  • Lack of haematinics, e.g. iron, vitamin B12, folate
  • Anaemia of chronic disease (infection, inflammation, malignancy)

8. Myelodysplasia (lack of healthy blood cells) is a sign of macrocytic anaemia. True or false?

  • True
  • False

9. If macrocytic anaemia has been caused due to a dietary lack of vitamin B12 or folate (i.e. its cause is not thought to be neurologically related), which drug would you recommend?

  • Cyanocobalamin
  • Hydroxocobalamin

10. What are the symptoms of anaemia?

  • All of the above
  • Exertional dyspnoea
  • Fatigue
  • Palpitations

11. What are the causes of anaemia of chronic disease?

  • All of the above
  • Chronic infection
  • Malignancy
  • Rheumatological diseases

12. What is anaemia?

  • A reduction in haematocrit
  • All of the above
  • A reduction in haemoglobin
  • A reduction in erythrocytes

13. What are the main causes of iron deficiency?

  • NSAID use
  • All of the above
  • Menstrual blood loss
  • Gastric ulceration
  • Coeliac disease

14. What are the haemoglobin criteria for men and women (over 18) for anaemia, according to WHO?

  • <120g/L for both men and women
  • <130g/L for men, <120g/L for women
  • <120g/L for men, <130g/L for women
  • <130g/L for both men and women

15. What is the main dietary source of vitamin B12?

  • Animal produce only
  • Greens
  • Mixture of animal products and greens

16. Normocytic anaemia is caused by anaemia of chronic disease. True or false?

  • True
  • False

17. How is autoimmune haemolysis diagnosed?

  • All of the above
  • Enlarged spleen
  • Raised reticulocytes
  • Strongly positive Coombs test

18. What does thalassemia result in?

  • Hepatospenomegaly
  • All of the above
  • Haemolysis
  • Ineffective erythropoiesis

19. What additional test can be used to confirm iron deficiency but is difficult to interpret in infection and inflammation?

  • EPO
  • Serum ferritin
  • Reticulocyte count
  • Vitamin B12 and folate

20. In sickle cell anaemia, haemoglobin S replaces both alpha-globin subunits in haemoglobin A. True or false?

  • False
  • True