adme principals

?
  • Created by: anna888
  • Created on: 31-01-23 17:20
define absorbtion
movement of molecules from admin site to blood stream. iv absorbtion is direct
1 of 32
3 methods of absorbtion over memebrane
simple diffusion, faciliated diffusion, active transport
2 of 32
describe simple diffusion
slow, spontaneuous, follows 1st order of kenetics (when conc increases, absorbtion rate increases)
3 of 32
describe facilitated diffusion
passive mediated, spontanoeus, transmembrane protiens ie carrier protiens or chanel protiens, no. of transmembrane protiens effects no. of molecules transported
4 of 32
describe active transport, what are the three methods
requires atp, fast, uniport- one molecule transported in one direction. antiport- movement of one molecule faciliates aothers movement eg ions. symport- 2 diff molecules, activateing e/o mechanims and working together
5 of 32
factors effecting absorbtion
physiological, physiochemical,dosage form, administartion route
6 of 32
what is Cp
conc of drug in plasma
7 of 32
what is Cmax
max conc of drug in plasma
8 of 32
what is Tmax
time when is Cmax
9 of 32
what is Dl
inital dose
10 of 32
what is Vd
distribution volume
11 of 32
what does auc represent, what is the equation
reflects the bodys exposure to the drug after dose admin. (D x F)/CL. where f is bioavialabity
12 of 32
what is bioavailability. what is the equation
amount of drug reaching the circulatory system from the delivery system. iv has 100% bioavailabity. f = auc oral/ auc iv x 100
13 of 32
factors effecting bioavailibity
lipid solubility, formulation, first pass effect
14 of 32
what is bioequivilance
ensures all drug formulations have the same bioavailibity
15 of 32
factors influencing distrubtion
molecular weight, polarity, blood flow, binding
16 of 32
factors influencing blood flow
excersies, cardiac problems, renal CL
17 of 32
two types of drug binding
ionic-weak, hydrogen-strong, determines intercations with protiens and binding sites
18 of 32
what are most weak acid drugs bound to
albumin
19 of 32
what kind of drug can pass a membrane
unbound only
20 of 32
equ for fraction of unbound drug
(unbound conc/ total conc) x100
21 of 32
what is vd and Vd equation
the volume of fluid that is required to provide the same conc as drug in blood plasma .dose of drug/ drug serum conc
22 of 32
metabolism main site and mechanisms
liver. using cytochrome p450s produced in hepatocytes. turn fat soluble drugs- water soluble
23 of 32
describe phase I reactions
functional groups added to make it more plar. via oxidsation and cyp450s, speifically the cyp 3a4 form
24 of 32
describe phase II reacions
conjugation to further increase solubility. mainly via glucuronidation via glucuronsyltranfarase
25 of 32
phase III reactions
transmembrane transport
26 of 32
what are three excretion routes
kidney as urine, liver as bile and faeces, lung as air
27 of 32
describerenal drug elimination (4)
1. filtration-unbound drugs only, albumin filtered out 2. reabsorbtion-lipophillic drugs only 3. secretion 4. excretion
28 of 32
what is renal CL
plasma volume that gets filtered of drug per unit time ml/min
29 of 32
what is roe and equation
rate of elimination of drug in grams. roe= CLrenal x C
30 of 32
descibe billary secretion
active secretion of drugs into bile and then into duodenum
31 of 32
half life equation, what does it determine
Ke= CL/Vd. determines dose and dose interval
32 of 32

Other cards in this set

Card 2

Front

3 methods of absorbtion over memebrane

Back

simple diffusion, faciliated diffusion, active transport

Card 3

Front

describe simple diffusion

Back

Preview of the front of card 3

Card 4

Front

describe facilitated diffusion

Back

Preview of the front of card 4

Card 5

Front

describe active transport, what are the three methods

Back

Preview of the front of card 5
View more cards

Comments

No comments have yet been made

Similar Biology resources:

See all Biology resources »See all adme resources »