Vitamin A - Advanced Nutrition II
- Created by: Ann
- Created on: 18-01-17 19:21
Vitamin A - retinoids and carotenoids
Vitamin A = all compounds that can form retinoids or retinol that can be a precursor to vitamin A; a generic term that possess the biological activity of all-trans retinol
Vitamin A is also an all encompassing term for retinoids and carotenoids but are not all interchangable
B-carotene is a carotenoid with the most of the vitamin A activity.
retinol can convert irreversibly to retinoic acid or retinyl ester
Retinol can also reversibly convert to retinal. (main form of biological activity)
You may consume retinyl ester, retinoic acid, and beta-carotene.
Beta-carotene is a carotenoid with the most vitamin A activity.
All-trans retinol is a retinol with a alcohol group. All bonds are in transformation and it contains an alcohol group. Can find in animal origin.
Retinal - has an aldehyde group
Retinal and all-trans retinol can convert back and forth reversibly.
Retinoic acid - with an acid group
All-trans retinol can form retinoic acid in growth
Retinyl esters - with a lipid group
Structure of carotenoids
Beta carotene is the one carotenoid with vitamin A activity.
Beta-carotene can be split to form two molecules of retinal
mg= microgram
12 mg of carotene need to = 1 mg retinol
Ex. 36 mg of carotene = 3 mg retinol
preformed vitamin A has more activity beta carotene takes more of it to convert.
Dietary Sources of Vitamin A
preformed vitamin A is more toxic and only found in animal sources
Preformed -retinyl ester (retinyl palmitate ex. of retinyl ester)
Liver
Egg Yolk
Dairy (fortified in United States)
Margarines (fortified)
Tuna, Sardines, Heerring
Cod Liver Oil
Beta-Carotene = exclusively in fruits and vegetables
Orange color - Carrots, squash, papayas, grapefruit, pumpkin
Green color - chlorofil over shadows the orange color - spinach, peas, broccoli, watermelon
Digestion and Absorption of vitamin A
animal sources and vegetable sources of (protein bound carotenoids and retinyl esters)
pepsin cleaves proteins (amino acids)
carotenoid and retinyl esters hydrolases, esterases and lipases
cleaves fatty acids
free caroteinoids and free reitnol
fatty acids combine with phospholipids, monoacylglycerol, and cholesterol and bile (makes it water soluble
incorporates into micelle
true of all fats and fat soluble vitamins
goes across intestinal cell
can either have beta carotene, retinol, or carotenoids
most are incorporated into chylomicrons that go into lymphatic system
beta carotene - can form two retinals (retinoic acid goes through the blood to the liver) or the retinal gets incorporated into chylomicrons combining with other
Vitamin A is primarily stored in the liver so it will be released into the blood stream as its needed.
Functions of Vitamin A
helps your vision = how you respond to bright light when its dark out
your eyes adjustment to light and dark
It's a specific form of Vitamin A : 11-cis retinal. This is a type of double bond cis is a c form.
its on the 11th carbon there is a double bond in the cis form. whereas for all the other biological function it is…
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