Sickle Cell Anaemia

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  • Created by: jenny
  • Created on: 05-10-15 10:00

Sickle Cell Anaemia

An inherited disease caused by a single subition mutation in one of the ploypeptide chains in heamoglobin

Haemoglobin is the red pigment in erythrocytes that transports oxygen.

Its made up of 4 chains, two being alpha and the other two beta

Normaly the base sequence that codes for the glutamates is usually CTT - In the faulty gene the triplet becomes CTA - Which now codes for valine

When the four polypeptides curl up they form a precise 3-D shape, and this has to do with the fact that some


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