Sickle Cell Anaemia
An inherited disease caused by a single subition mutation in one of the ploypeptide chains in heamoglobin
Haemoglobin is the red pigment in erythrocytes that transports oxygen.
Its made up of 4 chains, two being alpha and the other two beta
Normaly the base sequence that codes for the glutamates is usually CTT - In the faulty gene the triplet becomes CTA - Which now codes for valine
When the four polypeptides curl up they form a precise 3-D shape, and this has to do with the fact that some…