Pyruvate marks the end of glycolysis, the first stage of respiration. Pyruvate can also be turned back into glucose by reversing glycolysis, and this is called gluconeogenesis.
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- In the absence of oxygen pyruvate is converted into lactate or ethanol in anaerobic respiration.
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- In the presence of oxygen pyruvate enters the mitochondrial matrix to proceed with aerobic respiration.
- Once pyruvate has entered the inside of the mitochondria (the matrix), it is converted to a compound called acetyl coA.
- Since this step links glycolysis and the Krebs Cycle, it is referred to as the link reaction.
- In this reaction pyruvate loses a CO2 and a hydrogen to form a 2-carbon acetyl compound, which is temporarily attached to another coenzyme called coenzyme A (or just coA), so the product is called acetyl coA.
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