RCTS
- Created by: BKW
- Created on: 01-02-22 14:34
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- Randomised Control Trials
- What is it?
- At least 2 conditions (treatment and control)
- randomisation of pps into conditions
- RCT Lingo
- Arm
- A group of pps receiving specific treatment
- Primary outcome measure
- key target of the intervention
- Active/Passive control groups
- active = still receiving treatment. Passive = they do nothing
- Arm
- Types of RCT
- Parallel RCT
- EG Van der Donk et al 2015
- Randomised cross over trial
- All pps experience all conditions ABBA
- EG Oliveria et al (2017)
- Cluster Randomised trials
- Randomiseclusters not individuals
- EG schools may be randomised to receive training for certain approaches
- Wassermann et al 2015
- Randomiseclusters not individuals
- pragmatic RCTs
- mimic usual clinical practice - evidence in real world
- EG Hutchings et al 2007
- mimic usual clinical practice - evidence in real world
- Parallel RCT
- Pros
- Consideredgold standard for medical evidence
- Randomised cross over trials
- everyone gets 'treatment'
- each individual acts as own control - efficient
- everyone gets 'treatment'
- Cluster based RTs
- solution to the cons - stratified sampling
- blind the therapist/investigator
- solution to the cons - stratified sampling
- general pros
- high internal validity
- minimal exclusion criteria
- IAPT services
- high internal validity
- Cons
- Randomised cross over
- Carry over effects
- only good for short lived treatments of chronic disease
- Carry over effects
- Cluster based RT
- Be careful of Selection bias, balanced groups and blinding
- general probs
- old unsuccessful RCTs didnt have to be published
- PHarking/hacking
- External validity
- not all pps will stick to the protocol
- bias
- old unsuccessful RCTs didnt have to be published
- Morrison 2001 - cant be only source of evidence
- Randomised cross over
- What is it?
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