Inherited diseases

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  • Inherited Disorders
    • Polydactyly
      • When babies are born with extra fingers or toes
      • Most common form caused by a dominant allele
      • Inherited from parents
      • Can be removed
      • Polydactyly + heterozygous = 50% chance of passing on to your children
        • Half of your gametes contain the faulty dominant allele
      • Polydacyly + homozygus = 100% chance of passing on to your children
    • Some genetic disorders are more harmful than others like Huntington's
    • Cystic Fibrosis
      • Afects many organs in the body especially the lungs, digestive & reproductive system
      • Disorder of cell membrane that prevents movement of certain substances from one side to another
      • Mucus made by cells in many areas of body becomes thick & sticky
        • Organs can become clogged preventing them working
        • Pancreas can't make & secrete enzymes properly because tubes to small intestine are blocked
      • Reproductive system affected so many infertile
      • Treatment includes physiotherapy & antibiotics
        • Enzymes used to replace ones pancreas can't produce & thin mucus
        • No cure
      • Caused by recessive allele inherited from both parents
        • Parents usually don't have the disorder
          • Have dominant healthy allele
          • Carriers
        • 1 in 25 carry cystic fibrosis allele in UK
    • Curing Genetic Disorders
      • No way to cure genetic disorders yet
      • Hope genetic engineering will be the answer
        • Replace faulty alleles with healthy ones
      • Scientists working on gene replacement for cystic fibrosis

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