Inhaled Route of Delivery
- Created by: VictoriaAshworth
- Created on: 04-01-18 15:18
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- Inhaled Route of Delivery
- Conditions where the inhaled route is used
- Asthma
- COPD
- Cystic Fibrosis
- Advantages
- Smaller doses can be used
- Rapid absorption
- Minimise chemical and enzymatic drug degradation
- Avoid GI upset
- Avoid first pass metabolism
- Disadvantages
- Require complex delivery devices (cost)
- Difficult to use
- Low reproducibility of dose delivery
- Mucus layer in lungs limiting absorption
- Mucociliary clearance reduces retention time
- Oropharyngeal deposition - local side effects
- Types of inhalers
- Dry powder inhalers (DPI)
- Unit-dose devices
- Dose contained in hard gelatin capsule and placed individually into device prior to use.
- e.g. Handihaler®, Spinhaler®, Aerolizer®
- Multi-dose devices
- More convenient - no individual dose loading
- Drug filled into foil blister disc containing multiple doses, and loaded by patient
- e.g. Accuhaler®, Clickhaler®, Turbohaler®
- Unit-dose devices
- Pressurised metered dose (pMDI)
- Most popular
- Mixture of gas and liquid discharged from device
- Advantages
- Portable
- Low cost
- Contains many doses (up to 200)
- Reproducible doses
- Inert conditions protect drug
- Disadvantags
- Inefficient drug delivery (oropharyngeal impaction)
- Errors in administration
- Breath-actuated pMDI
- Useful for patients who have difficulty coordinating breathing and actuation
- Nebulisers
- Dry powder inhalers (DPI)
- Conditions where the inhaled route is used
- Inhaler technique from Chemist and Druggist
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