Genetic explanation for Schizophrenia

  • Created by: Georgia
  • Created on: 14-04-19 18:32
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  • Genetic explanation for schizophrenia
    • Outline (A01)
      • Closer relation = higher concordance (likely)
      • Polygenic - increased vulnerability
      • Research methods: twin, family and adoption studies
    • Research evidence
      • Gottesman and Shields (1982) ;;;; 46% concordance for MZ; 14% concordance for DZ
        • Suggests specific gene; genetics has huge influence as MZ > DZ
      • Tienari et al (2004) Children of schizophrenia patients still have heightened risk even when adopted
        • Suggests environment has no impact as gene already exists
      • Gottesman (1991) Schizophrenia more common in biological relatives; closer relation = higher risk
    • Evaluate (A03)
      • Impossible to pinpoint exact gene of cause
      • Not 100% concordance rate so must be another factor
        • Too reductionist; states must be biology when there is obviously another factor
      • Supported by research evidence; higher concordance rate than "normal"
      • Small sample sizes in studies; hard to generalise (rare to have twins with schizophrenia)
      • Family studies can't separate genes and environment so unreliable
        • Use adoption studies to separate
      • Too deterministic; states schizo must be inherited with genes when there is only a higher risk


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