Dopaminergic neurones

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  • Created by: Ellie0o0o
  • Created on: 21-04-15 07:31
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  • Dopaminergic Neurones
    • Pathway:
    • GPCR receptors
      • D1
        • Gs coupled
      • D2
        • Gi/o coupled
      • D3
        • Gs coupled
    • Vesicular Monoamine Transporter (VMAT)
      • Loads Dopamine into vescles
      • DAT - reuptake transporter
    • Used Dopamine...
      • Degradation by Monoamine oxidase
      • Recycling by
        • Vesicular Monoamine Transporter (VMAT)
          • Loads Dopamine into vescles
          • DAT - reuptake transporter
    • Drugs which impact...
      • COCAINE
        • Blocks DAT
        • Also impacts substantia nigra
      • AMPHETAMINES
        • Dopamine agonists
        • Packaged by VMAT
        • Lead to excess in synapse
      • OPIATES
        • Inhibit GABA which regulate dopamine
        • Act via Gi/o linked GPCR

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