Dopaminergic neurones
- Created by: Ellie0o0o
- Created on: 21-04-15 07:31
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- Dopaminergic Neurones
- Pathway:
- GPCR receptors
- D1
- Gs coupled
- D2
- Gi/o coupled
- D3
- Gs coupled
- D1
- Vesicular Monoamine Transporter (VMAT)
- Loads Dopamine into vescles
- DAT - reuptake transporter
- Used Dopamine...
- Degradation by Monoamine oxidase
- Recycling by
- Vesicular Monoamine Transporter (VMAT)
- Loads Dopamine into vescles
- DAT - reuptake transporter
- Vesicular Monoamine Transporter (VMAT)
- Drugs which impact...
- COCAINE
- Blocks DAT
- Also impacts substantia nigra
- AMPHETAMINES
- Dopamine agonists
- Packaged by VMAT
- Lead to excess in synapse
- OPIATES
- Inhibit GABA which regulate dopamine
- Act via Gi/o linked GPCR
- COCAINE
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