digestion and absorption

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  • digestion and absorption
    • digestion
      • larger molecules hydrolysed to smaller molecules
      • enzyme hydrolysis
        • lipases
          • lipids ->  monoglycerides + fatty acids
            • ester bond
          • made in pancreas and small intestine
            • bile salts produced in the liver and emulsify lipids
              • form micelles
              • larger SA:VOL
        • proteases
          • peptidases
            • endopeptidases
              • hydrolyse peptide bonds within a protein
              • made in pancreas, excreted in small intestine
              • e.g. trypsin and chymotryspin
            • exopeptidase
              • hydrolyse peptide bonds of terminal amino acids
            • Membrane-bound dipeptidases - hydrolyse peptide bonds in dipeptides
        • carbohydrases
          • Amylase - hydrolyses glycosidic bonds in starch, produces maltose
          • Maltase - hydrolyses glycosidic bonds in maltose, produces glucose
          • Membrane-bound disaccharidase (maltase, sucrase, lactase)
    • absorption
      • products of digestion are absorbed across the ileum into the bloodstream
      • monosaccharides
        • absorbed via active transport with sodium ions via co-transporter protein
          • amino acids
          • sodium ion concentrationgradient needed (ATP)
      • amino acids
      • monoglycerides and fatty acids
        • micelles are constantly breaking down and reforming
          • whole micelles not absorbed
        • lipid-soluble
          • non-polar
            • diffuse directly across epithelial cell membrane
    • adaptations
      • ileum
        • folded and has villi
          • increase SA
        • thin
          • shorter diffusion distance
        • contain muscle
          • can mix contents - maintaining gradient

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