Wuchereria bancrofti/Onchocerciasis

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  • Created by: bancrofti
  • Created on: 21-12-17 13:09
What disease does the W. bancrofti parasite cause?
Lymphatic filiarisis
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What type of transmission does W. bancrofti use?
Vector transmission
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What vector does W. bancrofti use?
Anopheles gambiae (mosquito)
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Is the parasite involved in lymphatic filariasis a nematode or a trematode?
Nematode (round worm)
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Describe step 1 of the life cycle (LF)
During a blood meal, the infected mosquito infects the human host with L3 filarial larvae
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Describe step 2 of the life cycle (LF)
Develop into adults, residing in the lymphatics
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Describe step 3 of the life cycle (LF)
Adults produce sheathed microfilariae daily
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Describe step 4 of the life cycle (LF)
Mosquito ingests the microfilariae during a blood meal
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Describe step 5 of the life cycle (LF)
After ingestion, microfilariae lose their sheaths, work their way through the wall of the proventriculus->cardiac portio of the midgut->thoracic muscles
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Describe step 6 of the life cycle (LF)
Microfilariae develop into L1 larvae->L2->L3
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Describe step 7 of the life cycle (LF)
L3 larvae migrate through the haemocoel to the mosquito's prosbocis
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Are the males larger than the females?
No
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What are the antigens secreted by L3 larvae?
GSTs, PGD-2
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What are the antigens secreted by the filarial worms?
PC-containing GPs
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What is the name of the other parasite with a similar life cycle to W. bancrofti?
Brugia malayi
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What is the difference between W. bancrofti and B. malayi?
B. malayi adults are smaller in size
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Microfilariae sense what in humans?
Circadian periodicity, specifically nocturnal
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What does a dead worm cause formation of? And what mediates this?
Granuloma formation, mediated by Wolbachia spp.
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What is the scientific name for the disease "river blindness"?
Onchocerciasis
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What form of transmission does onchocerciasis use?
Vector transmission
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What is the parasite involved in onchocerciasis?
Onchocerca volvulus
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What is the vector used in onchocerciasis transmission?
Similium damnosum (black fly)
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Name 3 types of pool-feeders
Similium damnosum, TseTse fly, Phlebotomus (sand fly)
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Describe stage 1 of the life cycle (O)
During a blood meal, the infected blackfly infects the human host with L3 filarial larvae
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Describe step 2 of the life cycle (O)
In subcutaneous tissue, the larvae develop into adults
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Describe step 3 of the life cycle (O)
Adults commonly reside in nodules in subcutaneous connective tissue
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Describe step 4 of the life cycle (O)
Female worms produce unsheathed microfilariae
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Describe step 5 of the life cycle (O)
Blackfly ingests microfilariae during a blood meal
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Describe step 6 of the life cycle (O)
Microfilariae migrate from the midgut->haemocoel->thoracic muscles
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Describe step 7 of the life cycle (O)
Microfilariae->L1->L3 larvae
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Describe step 8 of the life cycle (O)
L3 infective larvae migrate to the proboscis of the mosquito
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What are symptoms of onchocerciasis?
Sclerosing keratitis and chorioretinal atrophy of the eyes, severe pruritus, rash, subcutaneous nodules
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Is the parasite involved in onchocerciasis a trematode or a nematode?
Nematode (round worm)
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Other cards in this set

Card 2

Front

What type of transmission does W. bancrofti use?

Back

Vector transmission

Card 3

Front

What vector does W. bancrofti use?

Back

Preview of the front of card 3

Card 4

Front

Is the parasite involved in lymphatic filariasis a nematode or a trematode?

Back

Preview of the front of card 4

Card 5

Front

Describe step 1 of the life cycle (LF)

Back

Preview of the front of card 5
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