week 9 drugs finally!!!

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  • Created by: hadar
  • Created on: 07-05-16 19:47
Acyclovir- mechanism of action
Aciclovir triphosphate competitively inhibits viral DNA polymerase and competes with the natural deoxyguanosine triphosphate, for incorporation into viral DNA. Once incorporated, aciclovir triphosphate inhibits DNA synthesis by chain termination
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Lamivudine- mechanism of action
nucleoside analog reverse transcriptase inhibitor- lack of a 3'-OH group in incorporated nucleoside analogue prevents formation of 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated
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Interferon alpha - therapeutic effect
activating function (anti viral and anti tumour activity) and interfere with virus replication and tumour growth
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Interferon beta - therapeutic effect
modulating function and down regulated interferon gamma not alpha- mainly autoimmune disorders
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Interferon gamma - therapeutic effect
activating function (anti viral and anti tumour activity) and interfere with virus replication and tumour growth
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interferon alpha and gamma- mechanism of action
activation of macrophages which produce the necessary cytokines for lymphocytes both B and T. activation of NK cells → maintaining surveillance
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Entry inhibitors - mechanism of action
targeting CCR5, a co-receptor located on human helper T-cells. Required by the virus for stabilization of receptor binding – without CCR5 the virus binds but not a stable binding it will fall off.
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Nucleoside reverse transcriptase inhibitors (NRTI) and nucleotide reverse transcriptase inhibitors (NtRTI) - mechanism of action
inhibit reverse transcriptase- preventing other nucleosides from also being incorporated into the DNA chain because of the absence of a 3' OH group (this is needed for the next base pair to attach so 5’→3’’ chain stopped).
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Non-Nucleoside reverse transcriptase inhibitors (NNRTI)- mechanism of action
inhibit reverse transcriptase by binding to an allosteric site of the enzyme; NNRTIs act as non-competitive inhibitors
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Integrase inhibitors - mechanism of action
inhibit viral enzyme integrase- metal binding groups that compete for substrate with two Mg2+ ions at the metal binding site of integrase. Degraded through protosomic pathways.
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Protease inhibitors- mechanism of action
block viral protease- prevent the cleavage of gag and gag/pol precursor proteins.
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Other cards in this set

Card 2

Front

nucleoside analog reverse transcriptase inhibitor- lack of a 3'-OH group in incorporated nucleoside analogue prevents formation of 5' to 3' phosphodiester linkage essential for DNA chain elongation, and therefore, the viral DNA growth is terminated

Back

Lamivudine- mechanism of action

Card 3

Front

activating function (anti viral and anti tumour activity) and interfere with virus replication and tumour growth

Back

Preview of the back of card 3

Card 4

Front

modulating function and down regulated interferon gamma not alpha- mainly autoimmune disorders

Back

Preview of the back of card 4

Card 5

Front

activating function (anti viral and anti tumour activity) and interfere with virus replication and tumour growth

Back

Preview of the back of card 5
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