week 6 drugs

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  • Created by: hadar
  • Created on: 16-04-16 14:53
Carbimazole- mechanism of action
decreases the uptake and concentration of inorganic and converted to methimazole, it prevents the thyroid peroxidase enzyme from coupling and iodinating the tyrosine residues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T
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Carbimazole- therapeutic effect
reducing the production of the thyroid hormones T3 and T4 (thyroxine). thus reducing affects of hyperthyroidism
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Propylthiouracil- mechanism of action
central → inhibits the enzyme thyroperoxidase. Peripheral → inhibits the enzyme 5'-deiodinase, which converts T4 to the active form T3.
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Propylthiouracil- therapeutic effect
By action both centrally and peripherally to reduce T3 and T4 levels
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Propranolol- mechanism of action
ß-adrenergic antagonist and blocks both ß1 and ß2 receptors. blocks the action of adrenaline and noradrenaline. inhibiting sympathetic stimulation.
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Propranolol- therapeutic effect
reduction in resting heart rate, cardiac output, systolic and diastolic blood pressure, and reflex orthostatic hypotension.
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Doxazosin- mechanism of action
inhibiting the postsynaptic alpha(1)-adrenoceptors on vascular smooth muscle. inhibits the vasoconstrictor effect of circulating and locally released catecholamines (epinephrine and norepinephrine), resulting in peripheral vasodilation.
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Doxazosin- therapeutic effect
The primary effect of this inhibition is relaxed vascular smooth muscle tone (vasodilation), which decreases peripheral vascular resistance, leading to decreased blood pressure.
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Octreotide- mechanism of action
binds to somatostatin receptors. inhibit secretion of many hormones. • reduce secretion of fluids by the intestine and pancreas. • reduce gastrointestinal motility and inhibit contraction of the gallbladder.
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Octreotide- therapeutic effect
pharmacologic properties mimicking those of the natural hormone somatostatin.
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Bromocriptine- mechanism of action
dopamine agonist- , dopamine inhibits lactotrophs in anterior pituitary from secreting prolactin.
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Bromocriptine- therapeutic effect
inhibition of lactotroph release for hormone secreting tumours
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Card 2

Front

reducing the production of the thyroid hormones T3 and T4 (thyroxine). thus reducing affects of hyperthyroidism

Back

Carbimazole- therapeutic effect

Card 3

Front

central → inhibits the enzyme thyroperoxidase. Peripheral → inhibits the enzyme 5'-deiodinase, which converts T4 to the active form T3.

Back

Preview of the back of card 3

Card 4

Front

By action both centrally and peripherally to reduce T3 and T4 levels

Back

Preview of the back of card 4

Card 5

Front

ß-adrenergic antagonist and blocks both ß1 and ß2 receptors. blocks the action of adrenaline and noradrenaline. inhibiting sympathetic stimulation.

Back

Preview of the back of card 5
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