week 5 drugs

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  • Created by: hadar
  • Created on: 09-03-16 11:11
Cisplatin- mechanism of action
crosslinking can occur via displacement of the other chloride ligand, typically by another guanine. activate apoptosis
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Cisplatin- therapeutic affect
to destroy the cancer cells and elicit tumour shrinkage
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Vinblastine- mechanism of action
inhibition of mitosis at metaphase through its interaction with tubulin-microtubular proteins of the mitotic spindle, crystallization of the microtubule and mitotic arrest or cell death. suppress microtubule dynamics/reduce microtubule polymerisation
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Vinblastine- therapeutic affect
to destroy the cancer cells and elicit tumour shrinkage
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Doxorubicin- mechanism of action (1)
Intercalating activity- intercalates DNA by forming a covalent bond with guanine on one strand mediated by formaldehyde and hydrogen binds with the guanine on the opposing strand → causes inhibition of DNA replication
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Doxorubicin- therapeutic affect
to destroy the cancer cells and elicit tumour shrinkage
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Doxorubicin- mechanism of action (2)
Histone eviction from chromatin → indices changes to structure of chromatin and changes function of DNA
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Doxorubicin- mechanism of action (3)
Generation of free radicles → direct DNA damage, direct damage to proteins and cell membrane
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Doxorubicin- mechanism of action (4)
Inhibits the topoisomerase II enzyme and that prevents DNA relacation and therefore DNA transcription and replication is inhibited → inhibition of cell cycle, division and growth.
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Mitomycin- mechanism of action
potent DNA cross linker Mitomycin is activated in vivo to a bifunctional and trifunctional alkylating agent. Binding to DNA leads to cross-linking and inhibition of DNA synthesis and function
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Mitomycin- therapeutic affect
to destroy the cancer cells and elicit tumour shrinkage
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Card 2

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to destroy the cancer cells and elicit tumour shrinkage

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Cisplatin- therapeutic affect

Card 3

Front

inhibition of mitosis at metaphase through its interaction with tubulin-microtubular proteins of the mitotic spindle, crystallization of the microtubule and mitotic arrest or cell death. suppress microtubule dynamics/reduce microtubule polymerisation

Back

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Card 4

Front

to destroy the cancer cells and elicit tumour shrinkage

Back

Preview of the back of card 4

Card 5

Front

Intercalating activity- intercalates DNA by forming a covalent bond with guanine on one strand mediated by formaldehyde and hydrogen binds with the guanine on the opposing strand → causes inhibition of DNA replication

Back

Preview of the back of card 5
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