Treating pain

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What are some symptoms of sprained ankle
pain, inflammation and restricted movement
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what are the inflammation signs
heat, redness,swelling
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what does tissue damage cause release of
vasoactive and chemotactic factors increasing of blood flow and capillary permeability
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what do permeable capilaries allow an influx of in tissue damage
fluid and cells
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where do phagocytes migrate in tissue damage and what is this called
site of inflammation (called chemotaxis)
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which microorganisms destroy bacteria in tissue damage
phagocytes and antibacterial exudate
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what is the mech of action of NSAIDS
inhibit COX enzymes, reducing formation of prostaglandins
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what are prostaglandins
hormones created to trigger pain and inflammation to start healing process
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what do prostaglandins activate
the inflammatory resposnse
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which 2 other organs are prostaglandins involved in
gastroinstetinal tract and kidneys
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how do prostaglandins act in the gastrointestinal tract
inhibit acid synthesis and increase secretion of protective mucus
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how do prostaglandins act in the kidneys
increase blood flow
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what are the side effects of nsaids
bleeding, peptic ulcers, renal (kidney) failure
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what are some examples of over the counter NSAIDS
Ibuprofen, Aspirin, Naproxen
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why can't Aspirin be sold to children under 16
they might get Reye's syndrome.
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what is an example of a brand name of Naproxen and what is its use
Feminax, used for dysmenorrhoea (period pain)
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what are the primary advantages of NSAIDS
it does not cause stomach upset or bleeding problems like the NSAIDs
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what group of drugs is paracetamol classed under
non opiod analgesics
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what is the minimum age a child can use paracetamol
2 months
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what dosage forms can paracetamol be used in
liquid, iv and suppositories
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what are the rare side effects of paracetamol
rashes, blood disorders, fatal liver damage (overdose)
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what doses of paracetamol is fatal (hepatoxicity level)
over 75mg/kg
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what is the management of paracetanol overdose
Parvolex is taken as IV
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why can methionine also be taken in paracetamol overdose
if parvollex is unavailable or patient cannot tolerate parvolex
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why can activated charcoal also be taken in overdose
to reduce absorption of paracetamol, only up to 1 hour after overdose
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what is an opiod
any drug binding to opioid receptors in CNS
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what are some examples of opiods for pain
Codeine, morphine, diamorphine, oxycodone
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what are opioid analgesics used to treat
moderate to severe pain
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what are the side effects of using opiods
vomiting, Constipation, Drowsiness
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how do topical analgesics work
act as a counter irritant
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what is Sumatriptan
migraine relief medication
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how does sumatriptan exert its therapeutic effects
exerts agonist effects on intracranial blood vessels resulting in vasoconstriction
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what is the treatment for acute somatic pain
no medication, PRICE
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what does price stand for
protection, rest, ice, compression, elevation
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what is the 3 step WHO pain ladder
1)paracetamol, 2)add weak opioid, 3) add strong opiod
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eg strong opioid
morphine, fentanyl
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eg weak opioid
codeine, tramadol
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Other cards in this set

Card 2

Front

what are the inflammation signs

Back

heat, redness,swelling

Card 3

Front

what does tissue damage cause release of

Back

Preview of the front of card 3

Card 4

Front

what do permeable capilaries allow an influx of in tissue damage

Back

Preview of the front of card 4

Card 5

Front

where do phagocytes migrate in tissue damage and what is this called

Back

Preview of the front of card 5
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