Transmission across a synapse

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  • Created by: Aman
  • Created on: 06-05-14 19:43
What is the neurotransmitter across a cholinergic synapse called? -
Acetylcholine (acetyl = ethanoic acid)
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Step 1 in transmission across cholinergic synapse - AP
Arrival of AP at end of PRESYNPATIC neurone causes calcium ion channels to open. Ca2+ enters synaptic knob
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Step 2 in transmission across cholinergic synapse - Fuse
Influx of calcium ions causes vesicles to fuse with presynaptic membrane - releases acetylcholine into synaptic cleft
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Step 3 in transmission across cholinergic synapse - sodium
Acetylcholine molecules fuse with receptor cites on NA ion channel in postsynaptic membrane. Sodium ion channels open - Na+ diffuses in rapidly ALONG CONC. gradient
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Step 4 in transmission across cholinergic synapse - new
Influx of sodium ions generates new action potential in postsynaptic neurone
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Step 5 in transmission across cholinergic synapse - enzyme
Acetylcholine hydrolysed into ethanoic acid and choline by acetylcholinerase. Choline and thanoic acid diffuse back into presynaptic neurone. Breakdown of acetylcholine prevents it from generating a new AP.
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Step 6 in transmission across cholinergic synapse - mitochondria
ATP released by mitochondria, and combines choline and ethanoic acid into acetylcholine. Acetylcholine is stored in the vesicles for future use. Sodium ion channels close due to the absence of acetylcholine in their receptor sites
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Card 2

Front

Step 1 in transmission across cholinergic synapse - AP

Back

Arrival of AP at end of PRESYNPATIC neurone causes calcium ion channels to open. Ca2+ enters synaptic knob

Card 3

Front

Step 2 in transmission across cholinergic synapse - Fuse

Back

Preview of the front of card 3

Card 4

Front

Step 3 in transmission across cholinergic synapse - sodium

Back

Preview of the front of card 4

Card 5

Front

Step 4 in transmission across cholinergic synapse - new

Back

Preview of the front of card 5
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