Toxicity of elements

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1. Which of these elements resemble K+?

  • Mn (EE) increased excitability of CNS
  • Ti - degeneration of all cell types, including neuronal damage
  • Se (and essential element) causes blocking of dehydrogenases
  • As (AsH3 or As2O3) binds to S-H in enzymes
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2. Which of these non metals is showing the wrong info?

  • Nitrogen forms NO2- forms nitrosamines, causes oxidation of iron in heamoglobin, carcinoginc. Formation inhited by vit C and E
  • sulphur forms hydroxyl radical which causes cough/tears. caused industrial pollution
  • Carbon which forms CO,HCN, KCN inhibits the ctochrome oxidase by binding to FE2+
  • Sulphur forms H2S blocks enzymes containing heavy metal ion,

3. Toxic metals has many molecular mechanisms that are harmful which these is not a mechanism?

  • Changing the structure and function of membranes, increasing the toxicity of xenobiotics
  • Allowing an essential metal ion bind to a protien
  • By changing the cytoskeleton structure or effecting enzyme activity
  • Influencing metabolic routes and allowing multiplication of toxic radicals

4. Which of these statements is incorrect about alcohol intoxication?

  • 90% of ethanol is oxidised in the liver by alcohol dehydrogenase
  • Glycolic acid causes causes renal failure and oxalic acid metabolic acidosis
  • Methanol causes metabolic acidosis and brain damage
  • Ethyleneglycol - which is used for antifreezing/sweet taste.

5. Which of these is the elimination of the products from the body?

  • Sweat, air
  • Diet, air
  • Urine, Bile
  • Occupational


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