Toxicity of elements

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1. Which of these metal toxication statement is correct?

  • Mercury can be treated through Dialysis
  • Cadmium has (cumulative phenomenon) and accumalates in kidney and liver irreversible replacing Zn
  • Mercury is an Irreversible inhibtor cathelochomines. Enzymes dependant on selenium
  • Ba- can lead to hear failure. BaSO4 used in xrays
  • Cu causes inherited defect in ceruloplasmin synthesis. Results in poor Fe2+ absorption(radicals can then form fenton)
  • Be blocks enzymes that utilise Mg2+ and can damage skin/lungs
  • Cu accumalates in brain, liver, kidney. Cirrohosis, loss of coordination, mental disorders.
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2. Which of these statements is incorrect about alcohol intoxication?

  • Ethyleneglycol - which is used for antifreezing/sweet taste.
  • Methanol causes metabolic acidosis and brain damage
  • Glycolic acid causes causes renal failure and oxalic acid metabolic acidosis
  • 90% of ethanol is oxidised in the liver by alcohol dehydrogenase

3. Which of these non metals is showing the wrong info?

  • Nitrogen forms NO2- forms nitrosamines, causes oxidation of iron in heamoglobin, carcinoginc. Formation inhited by vit C and E
  • sulphur forms hydroxyl radical which causes cough/tears. caused industrial pollution
  • Carbon which forms CO,HCN, KCN inhibits the ctochrome oxidase by binding to FE2+
  • Sulphur forms H2S blocks enzymes containing heavy metal ion,

4. Toxic metals has many molecular mechanisms that are harmful which these is not a mechanism?

  • Influencing metabolic routes and allowing multiplication of toxic radicals
  • Allowing an essential metal ion bind to a protien
  • Changing the structure and function of membranes, increasing the toxicity of xenobiotics
  • By changing the cytoskeleton structure or effecting enzyme activity

5. Which metal ion does EDTA tend to form a ligand with?

  • Cu2+, Hg2+
  • Ca2+, Pb2+
  • Fe3+, Al3+


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