Toxicity of elements

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1. Which of these statements is incorrect about alcohol intoxication?

  • Ethyleneglycol - which is used for antifreezing/sweet taste.
  • Methanol causes metabolic acidosis and brain damage
  • Glycolic acid causes causes renal failure and oxalic acid metabolic acidosis
  • 90% of ethanol is oxidised in the liver by alcohol dehydrogenase
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2. Which of these metal toxication statement is correct?

  • Mercury is an Irreversible inhibtor cathelochomines. Enzymes dependant on selenium
  • Mercury can be treated through Dialysis
  • Cu accumalates in brain, liver, kidney. Cirrohosis, loss of coordination, mental disorders.
  • Cadmium has (cumulative phenomenon) and accumalates in kidney and liver irreversible replacing Zn
  • Ba- can lead to hear failure. BaSO4 used in xrays
  • Cu causes inherited defect in ceruloplasmin synthesis. Results in poor Fe2+ absorption(radicals can then form fenton)
  • Be blocks enzymes that utilise Mg2+ and can damage skin/lungs

3. Which metal ion does EDTA tend to form a ligand with?

  • Cu2+, Hg2+
  • Ca2+, Pb2+
  • Fe3+, Al3+

4. Which of these is incorrect about Lead?

  • Pathophysiology: strong interaction with SH groups, replacing other transition metals, decrease in red blood cells viability
  • treatment: removing chelating agents by adding antagnoists eg.ZN, Fe, Ca
  • Sources:Food, tap water from pb pipes, feul
  • Symptoms: abdominal pain, nausea, motor nerve dysfunction

5. Which of these elements are essential elements?

  • Cu, I, Fe
  • Se, Cr, Mn
  • Molybdenum, Iodinine, Lithum

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