The Tricarboxylic Acid Cycle

What is the tricarboxylic acid pathway otherwise known as?
The Krebs cycle
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What is the starting product?
Acetyl-CoA from the link reaction
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How many turns of the cycle is it per molecule of glucose?
2 as there is 2 pyruvate molecules from 1 glucose meaning 2 link reactions and 2 turns of the cycle
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Step 1
Condensation reaction, Acetyl CoA joins with oxaloacetate, (Enzyme: Citrate synthase), product: Citrate
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Step 2
Rearrangement, successive dehydration, removing water then re-adding it, (Enzyme: Aconitase), product: Isocitrate
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Step 3
Oxidative decarboxylation, NAD+ reduced, CO2 released, (Enzyme: Isocitrate dehydrogenase), cofactor: BMn2+, product: a-ketoglutarate
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Step 4
Oxidative decarboxylation, NAD+ reduced, CO2 released, (Enzyme: a-ketoglutarate dehydrogenase), Coenzyme: CoA-SH, Cofactor: Mg2+, product: Succinyl-CoA
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Step 5
Hydrolysis reaction, CoA is lost, (Enzyme: Succinyl-CoA synthase), 1 ATP produced, cofactor: Mg2+, product: succinate
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What are steps 6,7 and 8 purpose?
To regenerate oxaloacetate in order to make it a complete cycle
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Step 6
Oxidation, 1 FAD reduced, takes place in inner mitochondrial membrane, (Enzyme: Succinate dehydrogenase), product: Fumerate
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Step 7
Hydration reaction, (Enzyme: fumerase), product: Malate
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Step 8
Oxidation, NAD+ as hydrogen carrier so 1 reduced NAD+, 3 ATP, (Enzyme: Malate dehydrogenase), product: oxaloacetate
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What is the ATP yield from one turn of the TCA cycle?
12 ATP molecules (11 ATP from oxidative phosphorylation, 1 ATP from substrate level phosphorylation)
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What is the over all yield of ATP per 1 molecule of glucose?
38 ATP molecules (8 from glycolysis, 6 from link reaction, 24 from TCA cycle- from 1 molecule of glucose)
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Card 2

Front

What is the starting product?

Back

Acetyl-CoA from the link reaction

Card 3

Front

How many turns of the cycle is it per molecule of glucose?

Back

Preview of the front of card 3

Card 4

Front

Step 1

Back

Preview of the front of card 4

Card 5

Front

Step 2

Back

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