The Liver

HideShow resource information
Lobes
Right, left, quadrate and caudate
1 of 21
Periportal
Region of the lobule that is furthest from the central vein. Has the highest levels of oxygen in its blood supply and has the highest metabolic activity. It's active in protein synthesis and secretes glucose
2 of 21
Centrilobular
Region of the lobule that is closest to the central vein. Has the lowest amount of oxygen in its blood supply and the most enzymes from biotransformation. It is the most susceptible to damage and contains glucose removing cells
3 of 21
Mediolobular
The region of the lobule that is in the middle
4 of 21
Lobules
Hexagonal shaped and together form the lobes. Consist of: hepatocytes, sinusoidal lumen surrounded by endothelial cells, bile canaliculi connected to bile ducts.
5 of 21
Hepatic artery
One of the blood supplies to the liver. It delivers oxygenated blood from the general circulation
6 of 21
Hepatic portal vein
One of the blood supplies to the liver. It delivers deoxygenated blood from the small intestine containing nutrients (70% of the liver blood supply)
7 of 21
Hepatic vein
The blood vessel that drains blood from the liver
8 of 21
Space of Disse
The small space that separates the hepatocytes from the endothelial cells lining the sinusoid
9 of 21
Hormones
IGF-1, angiotensinogen, thrombopoeitin, hepcidin, betatrophin
10 of 21
Sinusoidal
System that filters the liver of toxic matter like dead cells, microorganisms, chemicals and drugs by use of Kupffer cells
11 of 21
Kupffer cells
Cells that break down and ingest toxic matter
12 of 21
Bile
A fluid containing bile salts, cholesterol, phospholipids, bilirubin, electrolytes and water
13 of 21
Bile salts
Critical for digestion and absorption of fats and fat-soluble vitamins in the small intestine. It is converted from cholesterol by hepatocytes
14 of 21
Proteins
Albumin, glycoproteins, HDL and LDL, blood clotting factors
15 of 21
Gallbladder
A small sac located under the liver. It serves as a reservoir until bile is needed in the small intestine to digest fats
16 of 21
Gallstones
Crystallised salts of bile due to a high concentration. When they are trapped going to the intestine, they cause pain. Two types - cholesterol and pigment stones of bilirubin
17 of 21
Hepatic steatosis
Simple fatty liver disease where excess fat accumulates in liver cells
18 of 21
NASH
Non-alcoholic steatohepatitis - where the excess fat in the liver causes inflammation
19 of 21
Fibrosis
Any form of persistent hepatitis, including steatohepatitis, which causes scar tissue to form within the liver
20 of 21
Cirrhosis
Where normal liver tissue is replaced with a lot of fibrosis. The structure and function of the liver are badly disrupted. Can lead to liver failure in severe conditions
21 of 21

Other cards in this set

Card 2

Front

Region of the lobule that is furthest from the central vein. Has the highest levels of oxygen in its blood supply and has the highest metabolic activity. It's active in protein synthesis and secretes glucose

Back

Periportal

Card 3

Front

Region of the lobule that is closest to the central vein. Has the lowest amount of oxygen in its blood supply and the most enzymes from biotransformation. It is the most susceptible to damage and contains glucose removing cells

Back

Preview of the back of card 3

Card 4

Front

The region of the lobule that is in the middle

Back

Preview of the back of card 4

Card 5

Front

Hexagonal shaped and together form the lobes. Consist of: hepatocytes, sinusoidal lumen surrounded by endothelial cells, bile canaliculi connected to bile ducts.

Back

Preview of the back of card 5
View more cards

Comments

No comments have yet been made

Similar Pharmacy resources:

See all Pharmacy resources »See all The Liver resources »