domain on outside of cell binds ligand specifically, causes a conformational change, opening the channel, flooding in of ions triggers next step in biological process
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G protein-linked receptors
ligand domain on cell surface detects signal, domain on inside of the cell that will trigger a signal as a response to ligand binding outside cell
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Cytoplasmic receptor
steroid hormone (ligand) enter the cell, complex formed between the hormone and the steroid hormone receptors, receptor dissociates from the chaperone, receptor enters the nucleus, acts as transcription factor
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Direct signal transduction
results from action of the receptor itself on effector proteins, protein kinase cascade, response is amplified
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Indirect transduction
uses second messenger to amplify the interaction between receptor binding and cellular reaction
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Second messengers
cAMP, cGMP, lipids, calcium ions, nitric oxide
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Serotonin
rapid increase in intracellular cAMP concentration, involved in pain control, sleep/wake control and mood
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Other cards in this set
Card 2
Front
signal transduction
Back
Wiring
Card 3
Front
responses
Back
Card 4
Front
receptor --> signal transduction pathway --> response
Back
Card 5
Front
secreted by one cell and detected by another cell that expresses the corresponding receptor
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