TB8 B&B Lecture 2; Structure and function of the hippocampus 0.0 / 5 ? PsychologyTB8 B&BUniversityNone Created by: mint75Created on: 24-04-16 19:35 What is a characteristic hippocampal cell field? Tightly folded 1 of 16 In the anterior/posterior gradient of the hippocampus, what does the posterior cortex receive more input from? The parahippocampal cortex, it has more place cells 2 of 16 In the anterior/posterior gradient of the hippocampus, what does the anterior cortex receive more input from? The amygdala and perirhinal cortex, encodes emotional memories and item familiarity/salience 3 of 16 Within the hippocampus, what are the main cell fields called? CA1 and CA3 4 of 16 Where does the hippocampus receive its input? Dendate gyrus 5 of 16 Where does the hippocampus output? Via the subiculum 6 of 16 According to Hebb (1949), what is LTM a result of? Structural modification of cell assemblies 7 of 16 What is the key premise of LTP? If a high frequency train follows a low frequency train ie. slight depolarisation the high frequency train drives a bigger response. Enhanced by LTP 8 of 16 What makes hippocampal cells special for LTP? Large amount of NMDA receptors @ the CA1 and CA3 synapses 9 of 16 How do NMDA receptors facilitate LTP? NMDA expel MG2+ from the channel, creating a greater influx of NA and CA and a greater action potential 10 of 16 What does glutamate bind to? AMPA receptors 11 of 16 Can LTP be produced by a SINGLE high frequency train? Yes, implying memory for single events is possible 12 of 16 What feature of LTP makes memory durable? Synaptic consolidation 13 of 16 What is the LTP feature of specificty? ONLY synapses active during the stimuation have increased responses and other pathways to the same neuron are not. 14 of 16 What is the LTP feature of associativity? Weak AND strong active pathways during the memory are enhanced and all aspects of the memory are bound together 15 of 16 In a study of transgenic mice, what was impaired when NMDA receptors on CA1 were knocked out? Spatial learning 16 of 16
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