Synaptic transmission 0.0 / 5 ? PsychologyNeuroscienceUniversityNone Created by: JessToLetYouKnowCreated on: 01-06-16 12:33 What is synaptic transmission related to? Processing 1 of 42 What opens when the AP reaches the presynaptic terminal? Calcium ion channels open 2 of 42 What is the first fundamental process? Manufacture - intracellular biochemical processes 3 of 42 What is the second? Storage in vesicles 4 of 42 What is the third? Release by AP 5 of 42 The fourth? Interact with postsynaptic receptors and diffuse across synapse 6 of 42 The fifth? Inactivation - breakdown/re-uptake? 7 of 42 What does ACH stand for and what is it? Acetylcholine and it is a transmitter substance 8 of 42 What gates ion channels relating to postsynaptic membrane effects Transmitters 9 of 42 What are the channels on the postsynaptic membrane sensitive to? Neurotransmitter substances 10 of 42 Name the three fast neurotransmitters ACH, GLU and GABA 11 of 42 Name the three neuromodulators DA, NA, 5HT 12 of 42 What is Dale's principle? "each neuron uses a different neurotransmitter" 13 of 42 Why is Dale's principle not strictly true? GLU and GABA use different modulators and modulatory systems can use different modulators 14 of 42 What is an endorphin? A pepticle with opiate-like effects 15 of 42 What do endorphins and opiates inhibit? Substance p, released by pain receptors 16 of 42 What do local anaestethics such as procaine and lignocaine do? Block AP and Na+ channels, well absorbed by mucous membranes 17 of 42 What is ACH affected by? Nicotine, Spider poison, poison from arrows (curare) and nerve gas 18 of 42 Which things that affect ACH are agonists? Nicotine and arrow poison (curare) 19 of 42 Which affects release? Spider Poison 20 of 42 How does nerve gas effect ACH? Blocks breakdown 21 of 42 Where is ACH widely used? Brain and spinal chord 22 of 42 Where does noradrenaline act as a transmitter? CNS AND PNS 23 of 42 How do stimulants effect it? Increase release and blocks re-uptake 24 of 42 How do MAO inhibitors effect it? Block release 25 of 42 How do anti-depressants effect it? Block re-uptake 26 of 42 What is dopamine important in? Basal ganglia 27 of 42 How do anti-psychotics affect it? Acts as receptor blocker 28 of 42 How do amphetamines/cocaine effect it? increase release and block re-uptake 29 of 42 How do anti-parkison's drugs e.g. L-DOPA effect it? Increase manufacture 30 of 42 What is the function of serotonin? Diverging projection in brain and supplies structure 31 of 42 How do SSRI's affect it? Effect reuptake 32 of 42 What does SSRI stand for? Selective Serotonin Re-uptake Inhibitor 33 of 42 How does MDMA effect it? Suggestions that it may be neurotoxic 34 of 42 How may hallucinogens e.g. LSD effect it? They act as a receptor agonist 35 of 42 Why does L-DOPA work for Parkinson's disease? Blocks release of dopamine 36 of 42 What is GABA? Main inhibitory transmitter 37 of 42 Which two types of drugs have inhibitory effects at GABA receptors? anti-convulsants and anti-anxiety (benzodiazepenes and valium) 38 of 42 Which type of drugs potentiate GABA effects? Anaesthetics and barbiturates 39 of 42 What is the main problem for drug design? Brain region for different function uses many different neurotransmitters, leads to side effects 40 of 42 What can L-DOPA cause in high doses? Psychosis 41 of 42 What can DA blockers or antipsychotics cause in high doses Parkinson's 42 of 42
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