Stem cells

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  • Created by: bukunmi
  • Created on: 15-05-19 12:23
Kim 2002
- ES derived DA neurons implanted into the rat Striatum innervated and survived, form functional synaptic connections and modulate spontaneous and pharmacologically induced behaviours.
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Hargus 2010
iPSC derived DA neurons made from PD and non-PD people survived in the rat host, and showed branching behaviour. at 16 wks only a few innervated but all showed functional improvements
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Kicuchi 2017
- human-iPSC derived neurons implanted into the straitum of primate model = increased spontaneous movement, improved motor function and innervation
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International stem cell corporation, 2017
Transplanted different does of SC into 12 PD striatum = 24-49% reduction in OFF time with dyskineseas, 19-33% increase in ON time, 15-47% increase in quality of life (not placebo controlled but evidence of dose-response effect)
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Kogut 2018
iPSC has very low efficiency (1/500-1000) somatic cells reprogram) but they have used a new technique to increase this to generate 4,019 iPSC colonies from 500 starting fibroblasts and reprogram up to 90.7% of individually plated cells
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Morizane, 2017
use Major histocompatability complex (MHC) matching, a technique used for donor organs, to improve survival rates of iPSC grafts - make a bank from 100 volunteers to match 93% of the population
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PISCES by ReNeuron - phase I
11 pps with SC in pallidum -improvements in limb function (national institute of health stroke scale) at 34 mo follow up and no adverse cell-related/immune effects
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PISCES by ReNeuron - phase II
23 pps w/sub acute stroke - positive response on the ARAT, mRS & BI
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PISCES by ReNeuron - phase III Ongoing
Ongoing placebo controlled trial
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Ji 2014
seed cells - seeded into scaffold to encourage production of more tissue; scaffold - mechanical support for seeds and vehicle for drugs; Growth factors
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Oh, 2012
ADSC improved function in rat model of SCI through angiogenesis and neurogenesis
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Koffler, 2019
Created 3D PEG scaffold and loaded it with progenitor cells in rat model of SCI. Damage cells regenerated across linearly, synapse onto NPCs implanted into the device and that implanted NPCs in turn extend axons out of the scaffold and into the host
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Varone, 2017
Silk antherea pernyi fibroin = (in vitro) good rigidity, RGD sequence for binding, no immune response, good degradation rate, brittle but can combine with chitosan
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Pieres 2015
Inflammation, loss of oligodendrocytes, demyelination = debris which causes apoptosis = ibuprofen reduce inflammation and myelin inhibition
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Pieres 2015
Gliar scar = mechanical barrier and source of regeneration inhibitors - can apply enzme to break down CSPGs, the main constituent of the scar
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Ben David 2011
iPSC have similar phenotype to cancer cells - expression of oncogenes, rapid proliferation, genomic instability (igh freq of mutations)
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Card 2

Front

iPSC derived DA neurons made from PD and non-PD people survived in the rat host, and showed branching behaviour. at 16 wks only a few innervated but all showed functional improvements

Back

Hargus 2010

Card 3

Front

- human-iPSC derived neurons implanted into the straitum of primate model = increased spontaneous movement, improved motor function and innervation

Back

Preview of the back of card 3

Card 4

Front

Transplanted different does of SC into 12 PD striatum = 24-49% reduction in OFF time with dyskineseas, 19-33% increase in ON time, 15-47% increase in quality of life (not placebo controlled but evidence of dose-response effect)

Back

Preview of the back of card 4

Card 5

Front

iPSC has very low efficiency (1/500-1000) somatic cells reprogram) but they have used a new technique to increase this to generate 4,019 iPSC colonies from 500 starting fibroblasts and reprogram up to 90.7% of individually plated cells

Back

Preview of the back of card 5
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