SPECIALIST COMMUNITY PUBLIC HEALTH NURSING 5

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METABOLISM USUALLY OCCURS CHIEFLY IN THE LIVER
IF LIVER IS IMPAIRED OTHER ORGANS MAY TAKE OVER, OTHER SITES WHERE METABOLISM WILL OCCUR ARE GASTRO-INTESTINAL TRACT, KIDNEY, MUSCLE, BRAIN, NERVES
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METABOLISM IS EFFECTED BY.....
HEPATIC BLOOD FLOW, ENZYME ACTIVITY CYTOCHROME P450, THE NUMBER OF HEPATOCYTES (CELLS)
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CYTOCHROME P450 IS......
A MAJOR HEPATIC ENZYME IN THE LIVER THAT CAN BE SPEED UP OR SLOWED DOWN
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ST JOHNS WORT......
SPEEDS UP CYTOCHROME P450 AND REDUCES THE EFFECT OF THE DRUG IN THE BLOOD EG CONTRACEPTIVES
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GRAPEFRUIT.....
SLOWS DOWN THE EFFECT OF THE DRUG IN THE BLOOD AND INCREASES ITS HALF LIFE AND RISK OF TOXICITY
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FIRST PASS EFFECT IS......
DRUG GOES INTO THE CIRCULATION AND PASSES THE HEPATIC VEIN TO THE LIVER
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METABOLISM OF DRUGS IS....
ALL THE PHYSICAL AND CHEMICAL CHANGES WHICH LEAD TO THE BREAKDOWN OF THE DRUG OR CHANGE IT TO A DIFFERENT SUBSTANCE (METABOLITES)
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Card 2

Front

METABOLISM IS EFFECTED BY.....

Back

HEPATIC BLOOD FLOW, ENZYME ACTIVITY CYTOCHROME P450, THE NUMBER OF HEPATOCYTES (CELLS)

Card 3

Front

CYTOCHROME P450 IS......

Back

Preview of the front of card 3

Card 4

Front

ST JOHNS WORT......

Back

Preview of the front of card 4

Card 5

Front

GRAPEFRUIT.....

Back

Preview of the front of card 5
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