1. CHANGE ROUTE, 2. DIFFERING DRUG RE COATING, 3. ROUTE OF ADMINSTRATION, 4. THERAPUETIC OBJECTIVES LOCAL OR SYSTEMIC EFFECTS
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WHAT EFFECTS DISTRIBUTION
7. PLACENTAL BARRIER - DRUG MAY GO INTO FOETUS OR STAY WITH MOTHER 8. BLOOD BRAIN BARRIER - STOPS PASSAGE OF LIPID SOLUBLE DRUGS IN THE CENTRAL NERVOUS SYSTEM 9. WATER SOLUBILITY - GENTAMICIN DIFFERING DOSES
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WHAT EFFECTS DISTRIBUTION.....
1. PHYSICAL PROPERTIES OF DRUG 2. BLOOD FLOW TO ORGAN 3. PROTEIN BINDING THAT EFFECTS DRUG 4. ALBUMIN LEVELS WILL EFFECT PROTEIN BINDING 5. HIGH LIPID SOLUBILITY, DRUG WILL NOT GO INTO FAT
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WHAT EFFECTS DISTRIBUTION...
6. DRUG INTERACTION - DISPLACEMENT OF ONE BOUND DRUG WITH ANOTHER 7. PLACENTAL BARRIER - DRUG MAY GO INTO FETUS OR STAY WITH MOTHER 8. BLOOD BRAIN BARRIER - STOPS PASSAGE OF LIPID INSOLUBLE DRUG IN CNS 9. WATER SOLUBILITY - GENTAMICIN
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DISTRIBUTION IS.....
A REFLECTION OF THE AMOUNT OF DRUG LEFT IN THE BLOOD STREAM AFTER ALL THE OF IT IS ABSORBED
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