A solid material with at least two different molecular arrangements
Polymorph
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The name when the crystallisation of compounds leads to entrapments of solvents within the crystal
Solvates
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The solvates recrystallise into a new form when the solvent is removed
Polymorphic solvates
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An ion that is already contained within a solution and increasing its concentration leads to a decrease in solubility
Common ion
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Adding an electrolyte to an aqueous solution of a non-electrolyte, decreasing the solubility of the non-electrolyte
Salting out
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The process of the removal of a solute molecule from a solid, the creation of a cavity in a solvent, and the insertion of the solute molecule in the cavity
Dissolution
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The conditions where absorption is faster than dissolution, and C (conc of bulk solution) doesn't exceed 10% of Cs (conc of solution at solid/solvent boundary)
Sink conditions
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The measure of dissolution which is independent of variables such as agitation and surface area
Intrinsic dissolution rate
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A dissolution equation for changing surface area
Hixson Crowell Cube Root Law
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Do symmetrical and compact drugs or amorphous drugs go into solution more easily?
Amorphous
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What does the van't Hoff Equation measure?
Mole fraction solubility
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The mixing of two crystalline solids together which results in a mixture that has a lower melting point than either of the components individually
Eutectics
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Chemically modifying drugs to produce a water-soluble derivative (which improves solubility)
Pro-drugs
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The general name of a water-miscible solvent that is added to alter the polarity of another solvent to ultimately increase its solubility
Co-solvents
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What do molecules which have a hydrophobic interior and hydrophilic exterior (amphiphilic molecules) form in aqueous solutions?
Micelles
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What is the interaction of a poorly soluble drug with a soluble material to form a soluble macromolecular complex called? (must also be reversible)
Complexation
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What is the name of hollow cylindrical molecules in a cyclic arrangement where part or all of the drug molecule is inserted into the hollow central cavity of the molecule?
Cyclodextrins
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What is the solubility of a drug when completely unionised (S0)?
Intrinsic solubility
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Differential Scanning Calorimetry - measures the amount of energy required to maintain the sample at the same temperature as the reference
DSC
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Equation that measures the solubility of a solid in an ideal solution
van't Hoff
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Other cards in this set
Card 2
Front
The name when the crystallisation of compounds leads to entrapments of solvents within the crystal
Back
Solvates
Card 3
Front
The solvates recrystallise into a new form when the solvent is removed
Back
Card 4
Front
An ion that is already contained within a solution and increasing its concentration leads to a decrease in solubility
Back
Card 5
Front
Adding an electrolyte to an aqueous solution of a non-electrolyte, decreasing the solubility of the non-electrolyte
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