Smythe Membrane and ER 0.0 / 5 ? BiologyCell BiologyUniversityNone Created by: SarahCreated on: 29-03-17 13:45 roles of the Rough ER? 1) storage, synthesis, transport, detoxification (SSTD) 1 of 31 what does the smooth ER release? Calcium ions 2 of 31 what do clathirin coats do? form vesicles at the cell surface and at the trans-golgi complex (side close to M) 3 of 31 what is revealed when a vesicle is uncoated? SNAREs 4 of 31 what does snare stand for? soluble N-ethylmaleimide sensitive factor adaptor protein receptor 5 of 31 what are COP 2 coats for? Golgi back and forward through complex 6 of 31 what are COP 1 coats for? form at ER at different sites, select proteins need to be secreted 7 of 31 what are snares? integral M proteins, have a TM domain anchors them in M, big cytoplasmic domains, small lumenal domains 8 of 31 what is formed to make vesicle fusion to occur? a SNARE complex, T and V snare wrap around each other 9 of 31 what is the snare called on the target membrane? T SNARE 10 of 31 how do we know about snare complexes? x ray crystalography 11 of 31 what do acinar cells relase in resonse to smooth ER releasing Ca ions? zymogen granules 12 of 31 what are zymogen granules for? digestive enzymes for the gut 13 of 31 how do zymogen granules leave acinar cells? Ca ion signalling --> exocytosis 14 of 31 how does the vesicle dock at the right place? only some T and V SNARES will pair with the right one 15 of 31 How many T SNARES are on the target for nerve terminals? 3 T SNAREs 16 of 31 what are the features of nerve terminal SNARE complexes? helical bundle consisting of 3 components allow vesicle to come very close 17 of 31 what is a powerful tool that can probe for membrane trafficking? botulinum toxins 18 of 31 what does botulinum toxins do? why useful? they target very particular snares, useful for understanding how SNAREs form 19 of 31 which way is the transport with ER and Golgi? ER --> Golgi 20 of 31 which face does the vesicles from the ER bind to on golgi? what is the last face? cis face --> trans face (CT) 21 of 31 why does each modification take place in a specific place in the golgi? each cisternae has specific enzymes eg for phospholyration of oligosaccharides 22 of 31 what are the 2 models for progression the golgi? vesicular transport model and cisternal maturation model 23 of 31 which progression model is correct? a mix of the 2 24 of 31 what is the vesicular transport model? golgi static, transport by vesicles 25 of 31 what is the cisternal maturation model? golgi dynamic, material continously fed in from ER and it matures, no back transport, progress from cis to trans 26 of 31 what are the 3 pathways that control movement of vesicles from trans Golgi? constitutive secretory pathway, signal mediated diversion to lysosomes or vesicles for secretion 27 of 31 the smooth ER is responsible for what? syn of phospholipid+cholesterol, steroid hormone, syn+ storgae of glycogen, glycerides and calcium store 28 of 31 what is the constitutive secretory pathway? trans golgi network to cell surface 29 of 31 an interaction between Ca and what exposes the myosin binding site for cross bridges? calcium ions and troponin 30 of 31 what is the 3 primary functions of the golgi apparatus? mod+packaging for exocytosis, renewal+mod of the plasma membrane, delivery of material to other organelles esp endocytic 31 of 31
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