Schizophrenia - SS2 - Explanations - Dopamine Hypothesis - Research

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Which 3 psychologists support the dopamine hypothesis?
Randrup & Munkvad, Davison & Neale and Van Kammon, Docherty & Bunney
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What did Randrup & Munkvad inject rats with?
Amphetamines - known to increase dopamine levels
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What did this cause?
Schizophrenic symptoms in rats
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What did Davison & Neale give schizophrenics?
Phenzothiazanes - a neuroleptic drug which blocks dopamine at the synapse
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What was found?
Symptoms were reduced
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What happened when Van Kammon, Docherty and Bunney gave schizophrenics amphetamines?
Their symptoms became worse
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How did Kane et al go against the dopamine hypothesis?
Found a new drug, clozapine to be ore effective - blocks dopamine less at synapse
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What practical applications are there?
Drugs to reduce dopamine and thus schizophrenic symptoms
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What can't be established?
If high dopamine led to schizophrenia or if schizophrenia caused high dopamine levels
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Card 2

Front

What did Randrup & Munkvad inject rats with?

Back

Amphetamines - known to increase dopamine levels

Card 3

Front

What did this cause?

Back

Preview of the front of card 3

Card 4

Front

What did Davison & Neale give schizophrenics?

Back

Preview of the front of card 4

Card 5

Front

What was found?

Back

Preview of the front of card 5
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