Disorganised Speech (problems speaking so listener can understand/changing topic) Disorganised behaviour (trouble making behaviour conform to everyday standards.
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Uncategorised symptoms?
Catatonia (move rapidly/repeat gestures), Catatonic Immobility (Hold unusual poses for long periods), Inappropriate effect (emotional response out of context).
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3 Phases of Schizophrenia?
1) Prodromal, 2) Active, 3) Residual
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Epidemiology basics?
3.2% population, onset mid 20s/early 30s, more common in men, often after period of stress
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Genetic Aetiology?
Family, Twin and Adoption Studies - high risk for family members, DZ twins and adopted with biological Sz mother.
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Dopamine theory?
Sz may be caused by over-activity or elevated levels of dopamine.
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Brain structure/function?
1) Enlarged ventricles
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What does the diathesis- stress model suggest?
Schizophrenia caused by vulnerability (predisposing factors) and triggered by life stresses.
1st Gen = treated positive symptoms, bad side effects, 2nd Gen = positive and disorganised symptoms but reduced immune system, 3rd Gen = as effective as 1st but less side effects.
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What is the MATRICS project?
Compares medications for each individual by assessing schizophrenia stage and choosing most appropriate medication.
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