Schizophrenia Key Research

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Gottesman and Shields
Adoption study of twins. Increased SZ when bio parent had SZ. All studies found high MZ (58%)than DZ (12%)
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Varma and Sharma:
reported a concordance rate pf 34.78% in first degree relatives of people with SZ and 9.2% in the controll group.
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The schizophrenia working group
DNA of 35,000 people w SZ, 110, 000 without. Found 128 genetic variations implicated in SZ
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Davis et al.
High levels of dopamine not in all SZ cases. Clozapine (treats SZ) has no DP blocking. Also high DP in mesolimbic = positive symptoms, high DP in mesocortical = negative symptoms
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Hoffman and Hampson
Explaining auditory hallucinations. Involves a complex functional loop, including Wernicke's area and putamen (involved in generation of spontaneous language)
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Card 2

Front

reported a concordance rate pf 34.78% in first degree relatives of people with SZ and 9.2% in the controll group.

Back

Varma and Sharma:

Card 3

Front

DNA of 35,000 people w SZ, 110, 000 without. Found 128 genetic variations implicated in SZ

Back

Preview of the back of card 3

Card 4

Front

High levels of dopamine not in all SZ cases. Clozapine (treats SZ) has no DP blocking. Also high DP in mesolimbic = positive symptoms, high DP in mesocortical = negative symptoms

Back

Preview of the back of card 4

Card 5

Front

Explaining auditory hallucinations. Involves a complex functional loop, including Wernicke's area and putamen (involved in generation of spontaneous language)

Back

Preview of the back of card 5

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