Adoption study of twins. Increased SZ when bio parent had SZ. All studies found high MZ (58%)than DZ (12%)
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Varma and Sharma:
reported a concordance rate pf 34.78% in first degree relatives of people with SZ and 9.2% in the controll group.
2 of 5
The schizophrenia working group
DNA of 35,000 people w SZ, 110, 000 without. Found 128 genetic variations implicated in SZ
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Davis et al.
High levels of dopamine not in all SZ cases. Clozapine (treats SZ) has no DP blocking. Also high DP in mesolimbic = positive symptoms, high DP in mesocortical = negative symptoms
4 of 5
Hoffman and Hampson
Explaining auditory hallucinations. Involves a complex functional loop, including Wernicke's area and putamen (involved in generation of spontaneous language)
5 of 5
Other cards in this set
Card 2
Front
reported a concordance rate pf 34.78% in first degree relatives of people with SZ and 9.2% in the controll group.
Back
Varma and Sharma:
Card 3
Front
DNA of 35,000 people w SZ, 110, 000 without. Found 128 genetic variations implicated in SZ
Back
Card 4
Front
High levels of dopamine not in all SZ cases. Clozapine (treats SZ) has no DP blocking. Also high DP in mesolimbic = positive symptoms, high DP in mesocortical = negative symptoms
Back
Card 5
Front
Explaining auditory hallucinations. Involves a complex functional loop, including Wernicke's area and putamen (involved in generation of spontaneous language)
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