Schizophrenia (Candidate genes)

What does candidate genes mean?
Schizophrenia is no longer considered to be caused by one gene but many - it is polygenic.
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Who conducted a key study to do with candidate genes?
Ripke et al
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When was this study conducted?
2014
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What was the proocedure of this study?
Carried out a huge study combining all previous data from genome wide studies. 37,000 people were compared with 113,000 controls.
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What are genome studies?
Genome studies look at the whole person and not just individual genes.
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What were the findings from this study?
It was found that 108 seperate genetic variations were associated with increased risk of schizophrenia; these included genes that were involved with the functioning of neurotransmitters.
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Name two problems with twin studies?
1. Separating genetics from the environment is difficult. 2. We may not see 100% concordance rate amognst MZ twins.
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Who conducted a key study to do with candidate genes?

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Ripke et al

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When was this study conducted?

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What was the proocedure of this study?

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What are genome studies?

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