Roehls disease

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  • Created by: Sarah
  • Created on: 24-05-17 17:57
what is an example of a Type 7 virus?
hepatitis B virus
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what types are dna viruses
type 1+2
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what are type 3 viruses?
segmented genomes
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what viruses type is retroviruses- enveloped-reverse transcriptase
type 6
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what type of virus is adenoviruses (resp disease, conjuctivition SV40), herpes virus (chicken pox, herpes sores, carcinomas and papilloma viruses: genital warts, cervical cancer
type 1
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what type of virus is papilloma viruses?
type 1
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what does papilloma virus cause?
genital warts and cervical cancer
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what does adenoviruses cause?
respiratory disease, sv40 and conjuctivitis
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what type of virus is segmented genomes?
type 3
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what is an example of a type 3 segmented genomesvirus?
rotavirus: acute gastorinitis
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what is type 4 virus?
makes polyproteins that are cleaved
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what examples of there of type 4 makes polypeptides that are cleaved?
polio viruses+ toga viruses: yellow fevers and SARS viruses
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what kind of virus is hyman t lymphotropic viruses like leumemia, and HIV (AD+IDS)
type 6- retroviruses
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what is type 5?
the viron carries RNA transcriptase
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what are examples of type 5 virion carries rna transcriptasE?
ebola viruses, influna viruses, paramyoviruses: measles
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what are viruses classed by?
genome type and how their mRNA strand is made
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what classification is used to classify dna?
baltimore classification
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what type is type 5
virion carires rna transcriptase
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what are examples of type 5?
influenza, ebola and paramyxociruses: measles
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what are type 6 viruses?
retroviruses envoloped rna transcrptase
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examples of type 6 reverse transcriptase enveloped rotaviruses?
HIV (aids), human lymphotrophic viruses: leukemia
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what are type 7 viruses?
double stranded DNA and reverse transcriptase
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what happens to type 7 dna?
dna made into genomic RNA
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what is an example of a type 7 virus?
hepatitis B virus
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papillomavirus causes 6% of all cancer in the world, but what allows early detection and curative treatment?
pap smear
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what is transformation?
accidental integration of virus into host chromosome
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what happens if the papillomavirus undegoes ransormation?
unbalanced production of viral replication -> malignant tumour
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what happens to papilloma virus if it doesnt undergo transformation?
beningn tumour infects epithelial cells and causes genital warts
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what is the first step of malignant tumour formation in pailloma virus
integration into host chromosome -> too much proliferation
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what do proteins produced by the viral genome in papilloma do?
upregulate DNA replication and proliferation by the host cell to allow more production of viral genome
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what allows more production of the viral genome?
upregulated: 1) proliferation 2) dna replication [by host cell]
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what does the papilloma virus genome contain several of?
oncogenes
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how many bp is the human genome?
3 billion bps
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what do E6 AND E7 usually do?
make more virus by turning up DNA replication machinery
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what is produced too much after transformation?
too much E6 and E7 turns up dna rep too much, unregulated cell proliferation
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what do E6 nad E7 bind to to stop constraints on dna replication?
Rb (E7) and p53 ( (E6)
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what are mis-regulation of rb and p53 usually involved with?
cancer (viral and non-viral)
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what does rb do?
binds to cell proliferation factor making it inactive
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how do retroviruses (type 6) cause cancer?
by incorporating human genes into their genome
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what human genes are incorporated into the virus genome?
proto oncogenes
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what happens when you innoculate 150 mice with MuLV?
results in 1 mouse with a tumour, it changed to Ab-MuLV
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the genes are altered when put in a viral genome how are they reffered to?
with a v-prefix, v-abl (viral), c-abl (host gene also called proto-oncogene)
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what does c-src usually do?
activate cell proliferation
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how does the cell normally downreg c-src?
phosphorylates one end of the protein, this causes the protein to fold in on itself+become inactive
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what does v-src not have that means c-src cant be switched off?
the c terminus no phosyphorylating -> not switched off
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what do many oncogenes encode?
host kinases which are always active now as they have lost regulation by fusion to viral genes or deletion of regulator sequences
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what types are dna viruses

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type 1+2

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what are type 3 viruses?

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Card 4

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what viruses type is retroviruses- enveloped-reverse transcriptase

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Card 5

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what type of virus is adenoviruses (resp disease, conjuctivition SV40), herpes virus (chicken pox, herpes sores, carcinomas and papilloma viruses: genital warts, cervical cancer

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