Regulation of transcription and translation

chapter 15.2 AQA Biology

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Define "transcriptional factor"
molecules that move into the nucleus from the cytoplasm and stimulate transcription
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How does oestrogen switch on a gene and therefore start translation?
1. binds with receptor site on transcriptional factor. 2. changes shape of receptor molecule. 3. releases inhibitor molecule so transcriptional factor can now enter nucleus and bind with DNA
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What does siRNA stand for?
small interfering RNA
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Does siRNA prevent or activate gene expression?
prevent
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How does siRNA work?
a strand of siRNa combines with an enzyme & guides it to and mRNA molecule & pairs up with its complimentary bases. The enzyme then cuts the mRNA into smaller sections. the mRNA now cannot be translated and the gene is not expressed.
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Name 2 ways siRNA could be used for medical/scientific purposes
used to identify the role of genes in a biological pathway, or block genes that cause diseases.
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Other cards in this set

Card 2

Front

How does oestrogen switch on a gene and therefore start translation?

Back

1. binds with receptor site on transcriptional factor. 2. changes shape of receptor molecule. 3. releases inhibitor molecule so transcriptional factor can now enter nucleus and bind with DNA

Card 3

Front

What does siRNA stand for?

Back

Preview of the front of card 3

Card 4

Front

Does siRNA prevent or activate gene expression?

Back

Preview of the front of card 4

Card 5

Front

How does siRNA work?

Back

Preview of the front of card 5
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Comments

Abby

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This is really good! What board is it for though? :-)

melvin

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AQA

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