Receptors

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Three cellular locations of receptors
Nuclear receptors, intracellula receptors, plasma membrane receptors.
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Example of nuclear receptors
oestrogen receptor, retinoic acid receptors. Zinc fingers
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Example of intracellular membrane receptors
Ryanodine receptor, iP3 receptor
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The three superfamiles of plasma membrane receptors
Ligand gated ion channels, GPCRs, intrinsic enzyme receptor superfamily
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The three subclasses of ligand gated ion channels
Nicotinic R like, ATP R, Ionotropic glutamate R
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Examples of nicotinic R like and the structure
nAChR, 5-HT3, GABAa, Glycine, ZAC. They have 5 subunits, each with 4 transmembrane domains.
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Examples of ATP R's
P2X - there are 7 subtypes. They have three subunits each with two transmembrane domains.
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Examples of ionotropic glutamate receptors
NMDA, AMPA, Kainate. they have 4 subunits, and the subunit has three TMD and a P loop between TMD 1 and 2
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Which types are inhibitory and what do they let through?
GabaA, Glycine, Cl-.
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The three families of GPCRs
Rhodopsin-like, metabotropic glutamate receptor like, Secretin receptor like.
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Examples of rhodopsin like GPCRs
there are lots - all 5-HT except 5-ht3. Noradrenaline receptor, mACh, opioid, dopamine
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Examples of metabotropic glutamate receptor like
mGlurs 1-8, gabaA
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Examples of secretin receptor like
VIP, Parathyrod hormone receptors
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Structure of rhodopsin like receptors
7 transmembrane domains with a ligand binding site on TMD 4.
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Structure of mGlur-like
7 transmembrane domain, with LBS on N terminal extracellar domain
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Families of intrinsic enzyme receptor families.
Receptor tyrosine kinases, receptor guanylate cyclase
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Example of RTK
Insulin receptor, nerve growth factor receptor TrkA
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Example of receptor guanylate cyclase
atrial natriuretic peptide recetpor
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How do intrinsic enzyme receptors usually function
dimerisation, autophosphorylation, and substrate phosphorylation
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Other cards in this set

Card 2

Front

Example of nuclear receptors

Back

oestrogen receptor, retinoic acid receptors. Zinc fingers

Card 3

Front

Example of intracellular membrane receptors

Back

Preview of the front of card 3

Card 4

Front

The three superfamiles of plasma membrane receptors

Back

Preview of the front of card 4

Card 5

Front

The three subclasses of ligand gated ion channels

Back

Preview of the front of card 5
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