Pulmonary drug delivery

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  • Created by: SamDavies
  • Created on: 23-04-19 22:37
What is an aerosol?
Solid or liquid dispersed in a gas
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What is the main disadvantage of nebulisers?
A large proportion of the dose is lost
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What is the main (flow-aiding) excipient found in dry powder inhalers?
Lactose
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What is the main disadvantage of DPIs?
Dose delivered is dependent on inspiratory effort
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Spinhaler, Rotahaler, Cyclohaler and Aerohaler are examples of which pulmonary drug device?
Single dose DPIs
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Diskhaler and Accuhaler are examples of which pulmonary drug device?
Multi dose DPIs
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What is the equation for aerodynamic diameter?
dae = d x sqrt p
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If a particle has a size between 5-10 um, where is it likely to be deposited
Upper airways
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If a particle has a size between 0.5-2 um, where is it likely to be deposited?
Alveolar region
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Why does propellant evaporation affect deposition?
Insufficient time for propellant evaporation leads to insufficient shearing in particle size
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How can breathing patterns improve deposition?
Holding breath after inhalation
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Other cards in this set

Card 2

Front

What is the main disadvantage of nebulisers?

Back

A large proportion of the dose is lost

Card 3

Front

What is the main (flow-aiding) excipient found in dry powder inhalers?

Back

Preview of the front of card 3

Card 4

Front

What is the main disadvantage of DPIs?

Back

Preview of the front of card 4

Card 5

Front

Spinhaler, Rotahaler, Cyclohaler and Aerohaler are examples of which pulmonary drug device?

Back

Preview of the front of card 5
View more cards

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