Psychopharmacology of Reward

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  • Created by: ksjvsba
  • Created on: 17-01-16 16:34
Olds and Milner
ICSS of rats
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Brain Reward Circuitry
Anterior Bed Nucleus of mFB -> ventral tegemental area -> nucleus accumbens -> ventral palladium
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Pecina (2003)
preserves 10% DAT resulting in 70% elevated dopermine. enhanced wanting but not show greate liking to sweet tastes
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Cues predicting reward...
elicit fluctuations in DA release, nucleus accumbens shell
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Beyene (2010)-
cue evoked DA release in NAc shell caries as a function of RM
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Cocaine
increases DA in NAc by blocking reuptake- extreme wanting
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Endocannabinoids (CHeer)
signalling via CB1R was necessary for DA release induced by cocoain, nicotine and ethanol.
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Anadamide.. (Williams and Kirkham 2002)
increases appetitive feeding behviour and increased consummatory behaviour. similar to THC
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Opiods -mediate food liking
reduce food intake and make previously nice meals not nice.
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Naxalone
- antagonist affect food intake but leave other feeding related parameters unaffected and other general behviours unaffected.
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Card 2

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Brain Reward Circuitry

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Anterior Bed Nucleus of mFB -> ventral tegemental area -> nucleus accumbens -> ventral palladium

Card 3

Front

Pecina (2003)

Back

Preview of the front of card 3

Card 4

Front

Cues predicting reward...

Back

Preview of the front of card 4

Card 5

Front

Beyene (2010)-

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