Psychopathy

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Damage to the vmPFC
associated with an increased risk of reactive aggression. Blair and Cipolotti, 2000.
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vmPFC damage is associated with deficits in moral judgement
(young, 2010)
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Selective damage to amygdala causes Kluver Bucy syndrome
Hayman 1998
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patients with amygdala lesions have deficits in the recognition of fearful expressions
calder et al, 1996. (Bach, 2013 counter)
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PSYCHOPATHY
‘high levels of aggression and antisocial behaviour performed without guilt or empathy for their victims’ (Dolan 1999)
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Born criminal
Lombroso, 1876
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Reduced grey matter
in orbito-frontal cortex and FOC - tilhonen 2008.
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There is a reduction in amygdala volume in psychopaths compared to healthy controls with volumes negatively related to PCL-R score
Yang, 2009
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BEHAVIOR - deficits in recognition of fearful faces.
Marsh 2008 - suggest amugdala dysfunction
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Reduced potentiation of eyeblink startle reflex in response to visual threat primes.
Patrick 1993 - suggest amygdala dysfunction
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Impairment on reversal learning tasks than healthy populations
Budhani, 2005. suggests an abnormailty in VMPFC
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Activation of vmPFCin reversal learning
Finger 2008 - psycopathic children different.
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Fusiform gyrus activation to fearful and neutral expressions
Highly atypical pattern. Deeley, 2006
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grey matter concentration in medial OFC and ACC
greater in children with callous unemotional traits. De Brito et al., 2009
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reduced autonomic reactivity to distressed faces
Suggests amygdala dysfunction - Blair 1997
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reduced activation of temporal structures, including amygdalahippocampus formation, during an affective memory task
Kiehl 2001
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WHITE MATTER
• Increasing evidence for WM disconnectivity between prefrontal and other brain regions in ASPD and psychopathy
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WM FA reduction in psychopaths, particuarly in CC and degree correlates with severity
Sundram 2013
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Reduced microstructural integrity of the uncinate fasciculus in psychopaths relative to controls
Craig, 2009
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What does the UF connect
The orbitofrontal cortex and the amygdala
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reporting reduced functional connectivity between the amygdala and prefrontal areas in conduct disordered () and CU () children.
Decety et al., 2009, Marsh et al., 2008
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Lack of CC means lack of interhemispheric modulation
Hiatt and Newmann, 2007
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CC psychothys had increased interhemispheric connectivity
Rainne 2003
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vmPFC damage is associated with deficits in moral judgement

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(young, 2010)

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Selective damage to amygdala causes Kluver Bucy syndrome

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Card 4

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patients with amygdala lesions have deficits in the recognition of fearful expressions

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Card 5

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PSYCHOPATHY

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