Proteins in action

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  • Created by: racheon
  • Created on: 04-03-14 18:54
What does the term 'quaternary structure' refer to?
The fact that some proteins are made up of more than 1 polypeptide subunit joined together, or a polypeptide and an inorganic component, and they only function if all the subunits are present.
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What might a quaternary structure involve in terms of polypeptides?
2 identical polypeptides coming together to form the final working protein, or a number of different polypeptide subunits coming together.
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What does haemoglobin's quaternary structure consist of?
4 polypeptide subunits: 2 α-chains and 2 β-chains.
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What does haemoglobin's quaternary structure make, and what type of protein is it?
A haemoglobin molecule which is a water-soluble globular protein.
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How is the tertiary structure of each haemoglobin subunit held in place?
By a number of bonds and interactions.
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Why is the specific shape of each tertiary structure in haemoglobin vital?
So the molecule can carry out its function.
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What is haemoglobin's function?
To carry oxygen form the lungs to tissues.
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How does haemoglobin carry out its function?
By binding oxygen to it in the lungs and then releasing it in tissues.
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What is the specialised part of each haemoglobin polypeptide, why is it special, and what is it responsible for in haemoglobin?
The haem group, which contains an iron ion and is responsible for the colour of haemoglobin.
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What is the word equation for haemoglobin and oxygen, and what colour is the haemoglobin at each point?
haemoglobin (purple-red)+oxygen->oxyhaemoglobin (red).
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What does an oxygen molecule bind to in haemoglobin?
The iron ion.
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How many oxygen molecules can bond to 1 haemoglobin?
4.
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What is the haem group not made of, and what type of group is it?
Amino acids, so it's a prosthetic group.
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What is collagen, and what is it made up of?
A fibrous protein made up of 3 polypeptide chains would around each other like rope.
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How many amino acids make up 1 coil of collagen?
1 000.
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What gives the collagen structure strength?
Hydrogen bonds between the collagen chains.
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How is the strength of collagen increased?
Each collagen molecule forms covalent bonds called cross-links with other collagen molecules.
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How are the cross-links arranged across collagen molecules?
They are staggered.
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What do many collagen molecules joined together form?
A collagen fibril.
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What do many collagen fibrils joined together form?
A collagen fibre.
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What is the function of collagen?
To provide mechanical strength.
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What does collagen do in the walls of arteries?
A layer of it prevents blood that's being pumped from the heart at a high pressure from bursting the walls.
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Tendons are mostly collagen. What do they do?
The connect skeletal muscles to the bones and form form a strong connection that allows them to pull the bones.
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What are bones formed from and why?
Collagen reinforced with materials to make them hard.
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What 2 other parts of the body are made of collagen?
Cartilage and connective tissue.
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What kind of treatments using collagen are becoming popular?
Cosmetic treatments.
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What is haemoglobin and what is collagen?
Haemoglobin is a globular transport protein, collagen is a fibrous structural protein.
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Compare and contrast haemoglobin and collagen.
H - globular, c - fibrous. H - soluble in water, c - insoluble. H - wide range of amino acids in it's primary structure, c - 35% of it's primary structure is 1 type. H contains a prosthetic group. Much of h-alpha helix, much of c - left-handed helix.
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Other cards in this set

Card 2

Front

What might a quaternary structure involve in terms of polypeptides?

Back

2 identical polypeptides coming together to form the final working protein, or a number of different polypeptide subunits coming together.

Card 3

Front

What does haemoglobin's quaternary structure consist of?

Back

Preview of the front of card 3

Card 4

Front

What does haemoglobin's quaternary structure make, and what type of protein is it?

Back

Preview of the front of card 4

Card 5

Front

How is the tertiary structure of each haemoglobin subunit held in place?

Back

Preview of the front of card 5
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