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6. Common protein phosphatases are ser/thr phosphatases PP1 PP2A and PP_
7. Under normal conditions, Keap 1 _____________ Nrf-2 degradation
8. Nrf-2 activity is regulated by the supressor proteins _______
9. Protein kinases have a regulatory mechanism where a large segment can be dynamically folded and unfolded in the course of cell functionin
10. The activity of protein kinases and posphatases can be regulated by___________ such as cAMP of Ca2+
- Second messengers
- Third messengers
11. Xenobiotic metabolism is aka
- Drug metabolism
- Urea metabolism
12. Conjugation, or binding of toxins makes them more polar and able to diffuse through membranes
13. When Nrf-2 dissociates from Keap1, it ___________
- Enters the nucleus
- Is degraded by 26S proteosome complex
14. ____________ can have a profound effect on the fitness and survival of an individual species
- Antrhopogenic toxins only
- Anthropogenic and natural toxins
- Natural toxins only
15. Toxins can only affect one type of organ
16. The ARE/EpRE core sequence TGACXXXGC is the __________
- Key DNA binding element for Nrf-2 gene regulation
- The inhibitor sequence for Nrf-2
17. NAD(P)H is a target gene in the ARE sequence
18. The part of the receptor __________ functions as a tyrosine kinase
- In the cytopasm
- In the extracellular fluid
19. __________ phosphorylates serene and threonine residues of many protiens
- cAMP- dependant protein kinase
- Ca2+ calmodulin dependant protein kinase type 2
20. Nrf-2 offers multi tiered mechanisms of protection, such as damage prevention, damage control and _________