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6. Common protein phosphatases are ser/thr phosphatases PP1 PP2A and PP_

  • 2B
  • F

7. Under normal conditions, Keap 1 _____________ Nrf-2 degradation

  • Promotes
  • Inhibits

8. Nrf-2 activity is regulated by the supressor proteins _______

  • MDM2
  • Keap3
  • Keap1
  • NICK

9. Protein kinases have a regulatory mechanism where a large segment can be dynamically folded and unfolded in the course of cell functionin

  • True
  • False

10. The activity of protein kinases and posphatases can be regulated by___________ such as cAMP of Ca2+

  • Second messengers
  • Third messengers

11. Xenobiotic metabolism is aka

  • Drug metabolism
  • Urea metabolism

12. Conjugation, or binding of toxins makes them more polar and able to diffuse through membranes

  • True
  • False

13. When Nrf-2 dissociates from Keap1, it ___________

  • Enters the nucleus
  • Is degraded by 26S proteosome complex

14. ____________ can have a profound effect on the fitness and survival of an individual species

  • Antrhopogenic toxins only
  • Anthropogenic and natural toxins
  • Natural toxins only

15. Toxins can only affect one type of organ

  • False
  • True

16. The ARE/EpRE core sequence TGACXXXGC is the __________

  • Key DNA binding element for Nrf-2 gene regulation
  • The inhibitor sequence for Nrf-2

17. NAD(P)H is a target gene in the ARE sequence

  • True
  • False

18. The part of the receptor __________ functions as a tyrosine kinase

  • In the cytopasm
  • In the extracellular fluid

19. __________ phosphorylates serene and threonine residues of many protiens

  • cAMP- dependant protein kinase
  • Ca2+ calmodulin dependant protein kinase type 2

20. Nrf-2 offers multi tiered mechanisms of protection, such as damage prevention, damage control and _________

  • Renewal
  • Review