Pituitary Disease

HideShow resource information
  • Created by: Becca
  • Created on: 24-12-13 16:16
When are dynamic stimulation tests done? How do they diagnose pituitary disease?
Hyposecretion suspected e.g. secondary hypthyroidism. TRH normally stimulates TSH. Failure to stimulate TSH/T4 indicates hormone insufficiency in TSH
1 of 8
When are dynamic suppression tests done? How do they diagnose pituitary disease?
Hypersecretion suspected e.g. acromegaly (GH tumour). Oral glucose tolerance test - high plasma glucose conc normally supresses GH release. Failure to suppress GH secretion indicates autonomous secretion (GH tumour)
2 of 8
How is pituitary disease managed?
Pharmacological management, surgery (craniotomy or trans-sphenoidal) & radiotherapy - potential side effects of hypopituitarism and damage to optic pathways
3 of 8
Name 4 specific pituitary diseases.
Hyperprolactinaemia, Acromegaly, Cushing's syndrome & Hypopituitarism
4 of 8
What causes hyperprolactinaemia? Symptoms? Treatment?
Cause: prolatinoma, damage to pituitary stalk. Symptoms: loss of fertility/libido, galactorrhoea, gynaecomastia. Treatment: dopamine receptor agonists (inhibit prolatin secretion & shrink tumour), surgery/radiotherapy (drug resistant tumours)
5 of 8
What causes acromegaly? Symptoms? Treatment?
Cause: excessive GH in adults (children = gigantism). Symptoms: coarsening of facial features, enlarged hands/feet. Treatment: surgical removal of tumour, radiotherapy, somatostatin analogues & dopamine receptor agonists (inhibit GH release)
6 of 8
What causes Cushing's syndrome? What is the treatment?
Cause: ACTH-secreting ant pituitary tumour (= Cushing's disease), excessive glucocorticoid activity, endo/exogenous (steroid medication). Treatment: tumour removal (radiotherapy for residual disease)
7 of 8
What is hypopituitarism? Causes? Treatment?
Deficiency of one or more pituitary hormones, pan-hypopituitarism = deficiency of all pituitary hormones. Caused by pituitary adenoma, surgery/radiotherapy/severe head trauma damages pituitary stalk. Treatment: hormone replacement
8 of 8

Other cards in this set

Card 2

Front

When are dynamic suppression tests done? How do they diagnose pituitary disease?

Back

Hypersecretion suspected e.g. acromegaly (GH tumour). Oral glucose tolerance test - high plasma glucose conc normally supresses GH release. Failure to suppress GH secretion indicates autonomous secretion (GH tumour)

Card 3

Front

How is pituitary disease managed?

Back

Preview of the front of card 3

Card 4

Front

Name 4 specific pituitary diseases.

Back

Preview of the front of card 4

Card 5

Front

What causes hyperprolactinaemia? Symptoms? Treatment?

Back

Preview of the front of card 5
View more cards

Comments

No comments have yet been made

Similar Medicine resources:

See all Medicine resources »See all Endocrinology resources »